Publications

Brain-machine interface

1.BioMEMS Sensor

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Huang WC, Lo YC, Chu CY, Lai HY, Chen YY, Chen SY (2017) Conductive nanogel-interfaced neural microelectrode arrays with electrically controlled in-situ delivery of manganese ions enabling high-resolution MEMRI for synchronous neural tracing with deep brain stimulation, Biomaterials, 122 :141-153. [PMID: 28119154]


Liu TC, Chuang MC, Chu CY, Huang WC, Lai HY, Wang CT, Chen SY, PhD and Chen YY (2015) Implantable Graphene-based neural electrode interfaces for electrophysiology & neurochemistry in in vivo Hyperacute Stroke Model. ACS Appl Mater Inter 8(1):187-96. [PMID 26653098]


Huang WC, Lai HY, Kuo LW, Liao CH, Chang PH, Liu TC, Chen YY* and Chen SY* (2015) Multifunctional 3D patternable drug-embedded nanocarrier-based interfaces to enhance signal recording and reduce neuron degeneration in chronic neural implantation. Adv Mater 27(28): 4186-93. [PMID: 26074252]


Lai HY, Albaugh DL, Kao YC, Younce JR, Shih YY* (2015) Robust deep brain stimulation functional MRI procedures in rats and mice using an MR-compatible tungsten microwire electrode, Magn Reson Med, 73(3):1246-51. [PMID: 24798216]


Chuang MC, Lai HY, Ho JA and Chen YY* (2013) Multifunctional microelectrode array (mMEA) chip for neural-electrical and neural-chemical interfaces: characterization of comb interdigitated electrode towards dopamine detection. Biosens Bioelectron 41:602-607. [PMID: 23083904]


Huang HY, Hu SH, Hung SY, Chiang CS, Liu HL, Chiou TL, Lai HY, Chen YY* and Chen SY* (2013) SPIO nanoparticle-stabilized PAA-F127 thermosensitive nanobubbles with MR/US dual-modality imaging and HIFU-triggered drug release for magnetically guided in vivo tumor therapy. J Control Release 172:118-127. [PMID: 23933522]


Lai HY, Liao LD, Lin CT, Shih YY, Chen YY*, Tsang S and Chang JY (2012) Design, simulation and experimental validations of a novel flexible neural probe for deep brain stimulation and multichannel recording. J Neural Eng 9:036001. [PMID: 22488106]


Huang HY, Hu SH, Chiang CS, Chen SY*, Lai HY and Chen YY* (2012) Self-Assembling PVA-F127 thermosensitive nanocarriers with highly sensitive magnetically-triggered drug release for epilepsy therapy in vivo. J Mater Chem 22:8566-8573.


Liao LD, Chang YJ, Lai HY, Lin CT, Lin ZM, Tsang S and Chen YY* (2012) A novel light-addressable multi-electrode array chip for neural signal recording based on VCSEL diode arrays. J NeuroSci NeuroEng 1:.4-12.


Chang YJ, Liao LD, Lin CT, Lai HY, Chen JL, Yang YT, Ting YC, Huang YP, Wu R, Thakor NV and Chen YY* (2012) A low-cost multielectrode array system for simultaneous acquisition of electrophysiological signal and cellular morphology. J NeuroSci NeuroEng 1:131-142.


Lee SY*, Su YC, Liang MC, Hong JH, Yang CM, Hsieh CH, Huang MY, Cheng CJ, Chen YY, Lai HY, Lin JW and Fang JQ (2011) A programmable implantable micro-stimulator soc with wireless telemetry: application in close-loop endocardial stimulation for cardiac pacemaker. IEEE T Biomed Circ S 5:511-512.


Chen YY*, Lai HY, Lin SH, Chao WH, Liao CH and Tsang S (2009) Design and fabrication of a polyimide-based microelectrode array: application in neural recording and repeatable electrolytic lesion in rat brain. J Neurosci Meth 182:6-16. [PMID: 19467262]



2.Neuromodulation

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Li SJ, Lo YC, Lai HY, Lin SH, Lin HC, Lin TC, Chang CW, Chen TC, Hsieh CJ, Yang SH, Chiu FM, Kuo CH, Chen YY* (2020) Uncovering the modulatory interactions of brain networks in cognition with central thalamic deep brain stimulation using functional magnetic resonance imaging, Neurosci, in press.


Chai WY, Chu PC, Tsai CH, Lin CY, Yang HW, Lai HY*, Liu HL* (2018) Image-guided focused-ultrasound CNS molecular delivery: An implementation via dynamic contrast-enhanced magnetic-resonance imaging, Sci Report, 7;8(1):4151. [PMID: 29515222]


Wang CF, Yang SH*, Lin SH*, Chen PC, Lo YC, Pan HC, Lai HY, Liao LD, Lin HC, Chen HY,  Huang WC, Huang WJ, Chen YY* (2017) A proof-of-principle simulation for closed-loop control based on preexisting experimental thalamic DBS-enhanced instrumental learning, Brain Stimul, 10 (2017) 672-683. [PMID: 28298263]


Lin HJ, Pan HC, Lin SH Lin, Lo YC, Shen E, Liao LD, Liao PH, Chen YW, Jaw FS, Chu KW, Lai HY*, Chen YY* (2016) Central thalamic deep-brain stimulation alters striatal-thalamic connectivity in cognitive neural behavior, Front Neural Circuit, 9(87). [PMID: 26793069]


Gong CS Alex, Lai HY*, Huang SH, Lo YC, Chen PY, Tu PH, Tang CY, Lin CC, Chen YY* (2015) A programmable high-voltage compliance neural stimulator for deep brain stimulation in vivo, Sensors, 15(6): 12700-12719. [PMID: 26029954]


Chu PC+, Liu HL+, Lai HY, Lin, CY, Tsai HC* and Pei YC* (2015) Neuromodulation accompanying focused ultrasound induced blood brain barrier opening. Sci Report 5:15477. [PMC 4614673]


Lai HY, Younce JR, Albaugh DL, Kao YC, Shih YY* (2014) Functional MRI reveals frequency-dependent responses during deep brain stimulation at the subthalamic nucleus or internal globus pallidus, NeuroImage, 84:11-18. [PMID: 23988274]



3.Neural Coding

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Chen BW#, Yang SH#, Lo YC, Wang CF, Wang HL, Hsu CY, Kuo YT, Chen JC, Lin SH, Pan HC, Lee QW, Yu Xiao, Qu Boyi, Kuo CH, Chen YY*, Lai HY* (2020) Enhancement of hippocampal spatial decoding using a dynamic q-learning method with a relative reward using theta phase precession, Int J Neural Syst, in press.


Yang SH, Chou C, Lo YC, Lai HY, Huang JW, Lin SH, Wang HL, Chen YK, Wang CF, Kao CC, Kuo CH, Chen YY* (2020) Inhibition of long-term variability in decoding forelimb trajectory using evolutionary neural networks with error-correction learning, Front Comput Neurosci, in press. 


Yang SH, Chen YY, Lin SH, Liao LD, Lu HH, Wang CF, Chen PC, Lo YC, Phan TD, Chao HY, Lin HC, Lai HY* and Huang WC (2016) A sliced inverse regression (SIR) Decoding the forelimb movement from neuronal spikes in the rat motor cortex. Front Neurosci 9:556 [PMID: 28018160]


Pei YC*, Chang TY, Lee TC, Saha S, Lai HY, Gomez-Ramirez M, Chou SW and Wong MK (2013) Cross-modal sensory integration of visual-tactile motion information: instrument design and human psychophysics. Sensors 13:7212-7223. [PMID: 23727955]


Lai HY, Chen YY*, Lin SH, Lo YC, Tsang S, Chen SY, Zhao WT, Chao WH, Shih YY, Chang YC, Tsai ST and Jaw FS (2011) Automatic spike sorting for extracellular electrophysiological recording using unsupervised single linkage clustering based on grey relational analysis. J Neural Eng 8:036003. [PMID: 21464520]


Neuroimage & Diseases

Yue Y, Jiang Y, Shen T, Pu J, Lai HY*, Zhang BR* (2020) ALFF and ReHo mapping reveals different functional patterns in early-and late-onset Parkinson's disease, Front Neurosci, 14:141.


Shen T, Hu J, Jiang YS, Zhao S, Lin CX, Yin XZ, Yan YP, Pu JL, Lai HY*, Zhang BR* (2019) Early-onset Parkinson’s disease caused by PLA2G6 compound heterozygous mutation, a case report and literature review, Front Neurol, 10:915. [PMID: 31496990]


Shen T, Pu JL, Lai HY, Xu LJ, Si XL, Yan YP, Jiang YS, Zhang BR* (2018) Genetic analysis of ATP13A2, PLA2G6 and FBXO7 in a cohort of Chinese patients with early-onset Parkinson's disease, Sci Report, 19;8 (1):14028. [PMID: 30232368]


Shen T, Zhao S, Jiang YS, Pu JL, Lai HY, Yan YP, Tian J, Chen YX, Zhang BR* (2018) Haplotype analysis on relationship of DNAJC6 gene with early-onset Parkinson’s disease risk in Chinese population. J Parkinson Dis, 9(1):1-12. [PMID: 30373961]


Lin SH, Lai HY, Yu-Chun Lo YC, Chou C, Chou YT, Wang CF, Liu GT, Jaw FS, Chen SY, Chen YY* (2017) Decreased Power but preserved bursting features of subthalamic neuronal signals in advanced Parkinson’s patients under controlled desflurane inhalation anaesthesia, Front Neurosci 11, doi:10.3389/fnins.2017.00701. [PMID: 29311782]


Bandla A, Liao LD*, Chan SJ, Ling JM, Liu YH, Shih YY, Wong TH, Peter TH, Lai HY, King N, Chen YY, Ng WH, Thakor NV (2017) Simultaneous functional photoacoustic microscopy and electrocorticography reveal the impact of rtPA on dynamic neurovascular functions after cerebral ischemia, J Cereb Blood F Met, doi: 10.1177/0271678X17712399. [PMID:28685662]


Liu YH, Liao LD*, Tan SSH, Kwon KY, Ling JM, Bandla A, Tan ETW, Shih YY, Li W, Ng W, Lai HY, Chen YY, Thakor NV (2015) Assessment of neurovascular dynamics during transient ischemic attack by the novel integration of micro-electrocorticography electrode array with functional photoacoustic microscopy, Neurobiol Dis, 82:455-465. [PMID: 26149348]


Lin SH, Chen SW, Lo YC, Lai HY, Yang CH, Chen SY, Chang YJ, Chen CH, Huang WT, Jaw FS, Chen YY* (2015) Quantitative measurement of Parkinsonian gait from walking in monocular image sequences using a centroid tracking algorithm, Med Biol Eng Comput, 54:485-496. [PMC: 4614673]


Liao LD*, Liu YH, Lai HY, Bandla A, Shih YY, Chen YY, Thakor N (2015) Rescue of cortical neurovascular functions during the hyperacute phase of ischemia by peripheral sensory stimulation, Neurobiol Dis, 75:53-63. [PMID: 25573087]


Liu TC, Chuang MC, Chu CY, Huang WC, Lai HY, Wang CT, Chen SY, Chen YY (2015) Implantable Graphene-based neural electrode interfaces for electrophysiology & neurochemistry in in vivo Hyperacute Stroke Model, ACS Appl Mater Inter, 8(1):187-96. [PMID:26653098]


Kao YC, Li WJ, Lai HY, Lin W, Shih YY* (2014) Dynamic perfusion and diffusion MRI of cortical spreading depolarization in photothrombotic ischemia, Neurobiol Dis, 71:131-139. [PMID: 25066776]



Shih YY*, Huang S, Chen YY, Lai HY, Du F, Hui ES, Duong TQ* (2014) Imaging neurovascular function and functional recovery after stroke in the rat striatum using forepaw stimulation, J Cereb Blood F Met, 34:1483–1492. [PMID: 24917039]


Liao LD, Bandla A, Ling JM, Liu YH, Chen YY, King NK, Lai HY, Ng WH, Thakor NV* (2014) Special section on the brain initiative: Improving neurovascular outcomes with bilateral forepaw stimulation in a rat photothrombotic ischemic stroke model, Neurophotonics, 1:011007.



Liao LD, Tsytsarev V, Delgado-Martinez I, Li ML, Erzurumlu R, Lin YR, Vipin A, Lai HY, Chen YY, Thakor NV* (2013) Neurovascular coupling: in vivo optical techniques for functional brain imaging, BioMed Eng OnLine, 12:38. 


Shih YY*, Chen YY, Lai HY, Kao YC, Shyu BC, Duong TQ* (2013) Ultra-high-resolution fMRI and electrophysiology of the rat primary somatosensory cortex, NeuroImage, 73:113-120. [PMID: 23384528]


Shu TY+, Lai HY+, Chang YC, Kuo YH, Chiou SM, Lu MK, Lin YC, Liu YL, Chen CC, Huang CH, Chien TF, Lin SZ, Chen YY*, Tsai CH* (2012) The role of the sub-thalamic nucleus in volitional movement termination in Parkinson’s disease. Exp Neurol, 233:253-263. (+: equal contribution) [PMID: 22056940]


Chen YY*, Cho CW, Lin SH, Lai HY, Lo YC, Chen SY, Chang YJ, Huang WT, Chen CH, Jaw FS, Tsang S, Tsai ST (2012) A vision-based regression model to evaluate parkinsonian gait from monocular image sequences, Expert Syst Appl, 39:520-526.


Liao LD, Lin CT, Shih YY, Lai HY, Zhao WT, Duong TQ, Chang JY , Chen YY*, Li ML* (2012) Investigation of the cerebral hemodynamic response function in single blood vessels by functional photoacoustic microscopy, J Biomed Opt, 17:061210. [PMID: 22734740]


Liao LD, Lin CT, Shih YY, Duong TQ, Lai HY, Wu R, Tsang S, Chang JY, Li ML*, Chen YY* (2012) Transcranial imaging of functional cerebral hemodynamic changes in single vessels using in vivo photoacoustic microscopy, J Cereb Blood F Met, 32:938-951. [PMID: 22472612]


Chao WH, Lai HY, Shih YY, Chen YY*, Lo YC, Lin SH, Tsang S, Jaw FS (2012) Correction of inhomogeneous magnetic resonance images using multiscale retinex for segmentation accuracy improvement, Biomed Signal Proces, 7:129-140.


Chen SW, Lin SH, Liao LD, Lai HY, Kuo TS, Lin CT, Chen YY* (2011) Quantification and recognition of parkinsonian gait from monocular video images using kernel-based principal component analysis, BioMed Eng OnLine, 10:99. [PMID: 22074315]


Liao LD, Li ML, Lai HY, Shih YY, Lo YC, Tsang S, Chao CP, Lin CT, Jaw FS, Chen YY* (2010) Imaging brain hemodynamic changes during rat forepaw electrical stimulation using functional photoacoustic microscopy, NeuroImage, 52:562-570. [PMID: 20362680]