LABS

Introduction

Dr. Xinjian Li received his Ph.D. degree in Institute of Neuroscience, Chinese Academy of Sciences. Then he took three round of Post-doctoral training in Hong Kong polytechnic University (Hong Kong), Johns Hopkins University(USA) and National institute of Health (NIH, USA). During his research, he used Drosophila, mouse, rat, marmoset and macaque to study fine movement control, neuropathic pain, schizophrenia, decision making, sleep and learning & memory. In his Post-doctoral training in NIH, he made great achievement in developing single-cell calcium imaging methods in freely behavior animals. Then he studied the corticospinal neurons in movement control (Cell, 2017) and neuropathic pain(Nature2018). In 2019, he continues his reach on Fine Motor Control and Navigation in Zhejiang University. 

 

Research Interests:

Voluntary movement is one of the basic skills critical for our daily life and social interactions.  It receives direct and indirect cortical control in addition to spinal cord circuit regulation. Cortical damage results in permanent motor deficits after spinal cord injury or stroke. Elucidating the complexity of the cortical motor control system will therefore be necessary for development of a more effective pharmaceutical and brain-machine interface based on intervention approaches. Take advantage of mouse and marmoset, Dr. Li will first investigate: skillful movement control, skillful technique learning and the mechanism of related disease.

Except fine movement control, animals and human will navigate to explore the surrounding environments.  Some brain regions (for example: Hippocampus, Entorhinal Cortex) have been extensively studies and were proved related to spatial navigation. But it is still unknown how different navigation-related information (animal’s location, environment context and animal’s action) integrated inside brain.


Research direction:    Fine movement control; Spatial Navigation; Brain-machine Interface; Movement-related disease 


Representative Publications:

1) Liu Y*, Latremoliere A*, Li Xinjian*, Zhang Z*, Chen M, Wang X, Fang C, Zhu J, Alexandre C, Gao Z, Chen B, Ding X, Zhou JY, Zhang Y, Chen C, Wang KH, Woolf CJ, He Z. Touch and tactile neuropathic pain sensitivity are set by corticospinal projections. Nature. 2018 Sep;561(7724):547-550. (*Co-first author, equal Contribution)

2) Xuhua Wang*, Yuanyuan Liu*, Xinjian Li*, Zicong Zhang*, Hengfu Yang, Yu Zhang, Philip R. Williams, Noaf S. A. Alwahab, Kush Kapur, Bin Yu, Yiming Zhang, Mengying Chen, Haixia Ding, Charles R. Gerfen, Kuan Hong Wang, Zhigang He, Deconstruction of corticospinal circuits for goal-directed motor skills, Cell 171, 1–16, October 5, 2017 ª, (*Co-first author, equal Contribution)

3) Li XinjianCao VY, Zhang W, Mastwal SSLiu QOtte SWang KH. Skin suturing and cortical surface viral infusion improves imaging of neuronal ensemble activity with head-mounted miniature microscopes, J Neurosci Methods. 2017 Aug 19. pii: S0165-0270(17)30297-2. 

4) Gao LLi XinjianYang WSun X, Modulation of azimuth tuning plasticity in rat primary auditory cortex by medial prefrontal cortex. Neuroscience. 2017 Apr 7; 347:36-47

5) Chen X, Guo Y, Feng J, Liao Z, Li Xinjian, Wang H, Li X, He J, Encoding and retrieval of artificial visuoauditory memory traces in the auditory cortex requires the entorhinal cortex. J Neurosci. 2013 Jun 12; 33(24):9963-74.

6) Xinjian Li, Feng Yu, Aike Guo, Sleep deprivation specifically impairs short-term olfactory memory in Drosophila. Sleep, November 1, 2009; 32(11): 1417-24.

 

 


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