Welcome to ZIINT

INTERDISCIPLINARY INSTITUTE OF NEUROSCIENCE AND TECHNOLOGY

SHARED PLATFORM

   INTERDISCIPLINARY INSTITUTE OF NEUROSCIENCE AND TECHNOLOGY

7T TEAM

    INTERDISCIPLINARY INSTITUTE OF NEUROSCIENCE AND TECHNOLOGY

MAGNETOM 7T MRI

               INTERDISCIPLINARY INSTITUTE OF NEUROSCIENCE AND TECHNOLOGY

GRADUATE SCHOOL OF ZJU

WELCOME TO JOIN US

   INTERDISCIPLINARY INSTITUTE OF NEUROSCIENCE AND TECHNOLOGY

      620-22日,由中国工程院和美国工程院联合举办的2019年度中美工程前沿研讨会( China-American Frontiers of Engineering Symposium, 简称CAFOE)在美国加州圣迭戈举行。CAFOE是中美两国工程院共同主办的重要学术交流活动,旨在为中美两国的优秀青年工程师和科研人员提供一个具有交叉学科特色的互动平台,对工程领域的前沿科学问题进行交流,对工程技术的实践与应用进行探讨,从而让两国青年科研人员能够进行深度的国际交流与合作。经过主办方长达三个月时间的考验和选拔,中国工程院对来自全国各地众多推荐和报名候选人的技术前沿性、学术水平和英语交流能力等进行了严格考察,最终确定28人入选本次研讨会,围绕“智慧城市、新材料、神经工程和5G无线通讯技术"等工程学科的前沿领域和热点问题展开研讨与交流。


   浙江大学系统神经与认知科学研究所赖欣怡教授不仅成功获选为2019年度中美工程前沿研讨会中方大会报告人(中方8名、美方8名)之一,并代表神经工程领域作了题为Development and Prospect of Neuromodulation Technology的大会报告,展示了浙江大学青年科学家在神经工程领域的实力和潜力。


  为表彰参会代表在工程领域的杰出贡献,中国工程院首次授予参会的中方代表“中国工程前沿杰出青年学者”称号,并由中国工程院院士程京为获选人颁发证书。图片1.png

赖欣怡教授与中国工程院程京院士合影

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 赖欣怡教授与美国工程院院长John Anderson院士合影 


自2009年起,中美两国工程院联合主办“中美工程前沿研讨会”,每两年举办一届,轮流在两国召开。每届会议由中美双方各指定一位主席,并各自遴选出约30位本国优秀中青年工程师和科研人员参会。主办方对参会者具有非常严格的选拔程序和要求。参加者须为年龄45周岁以下(1974年1月1日以后出生),了解并熟悉本领域的前沿技术,具有较高的学术水平,能熟练运用英语写作及交流,特别是有较强的英语口语能力。研讨会最大特点是将不同领域的专家聚集在一起,鼓励他们进行跨学科交流,从而促进学科间合作,碰撞创新火花。

本届研讨会由中国工程院程京院士和美国工程院鲍哲南院士担任主席,中国工程院副院长王辰院士、美国工程院院长C. D. Mote, Jr.致欢迎辞并全程参会


图片3.png    赖欣怡教授2019年中美工程前沿研讨会大会报告

 

图片4.png          2019年中美工程前沿研讨会会人员大合


2019-07-02 READ MORE

How do our brains enable us to see the many shapes of objects in the world? One idea posed by neuroscientists is that there are different types of neurons in the brain that recognize different elements of shape, such as straight lines, curves, and corners, and that shapes are the result of integrating these different basic elements. However, where these neurons are and how their information is integrated is not well understood. 


图片1.png  

  

In the late 1960s, Nobel Laureates Hubel and Wiesel discovered that the first stage of visual information processing in the cortex (primary visual cortex) contains submillimeter-sized functional units called orientation columns. They showed that each column contained neurons responsive to only a certain contour orientation (e.g. neurons in a ‘vertical’ orientation column would respond to the vertical contour of a tall tree but not to the contour of a horizontal tree branch). It was later discovered that the set of all possible orientation columns (0-180 deg) shifted systematically around a point in a ‘pinwheel-like’ fashion. This concept of a single orientation column encoding a single contour orientation has been a cornerstone of sensory systems neuroscience.


In this study, two research teams cooperated to develop a novel, highly precise method of targeting electrodes in the orientation column and accurately determinng their position, so that different regions within single orientation columns could be probed. Using intrinsic signal optical imaging to map the orientation columns, researchers conducted systematic and comprehensive study of the functional properties of neurons in different parts of individual orientation columns. For the first time, they found that within single orientation columns there is a clear distribution of neurons with different functional preferences. Specifically, they found three subdomains, whose functional responses were consistent with the encoding of straight lines, curves, and complex contours, respectively. This suggested that single orientation columns may contain multiple basic elements for building shapes and led to a new concept of the ‘pinwheel-centered orientation hypercolumn’. Thus, their technical advance has led to a new view of the orientation column and of cortical functional architecture. This new finding will also be useful for computational models of shape encoding in the brain.

 

图片2.png 

 

Online Paperhttps://advances.sciencemag.org/content/5/6/eaaw0807


2019-06-06 READ MORE
2019-07-05 READ MORE


经浙江大学系统神经与认知科学研究所学生委员会对申报材料的综合审核,同意以下学生参加2019年夏令营。

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一、夏令营活动信息:

1. 夏令营活动时间:710日至712日;

2. 报到时间:71010:00-13:30(提供午餐),夏令营主办方提供710-11日两天的住宿,71214:00前退房,710日无法报到者,取消参营资格;

3. 报到地点:锦江之星(凯旋路店),地址:杭州市江干区凯旋路451号,电话:0571-86711111

二、营员准备工作:

1. 62814:00前填写参营回执(附件1),与身份证、学生证、外语成绩单、学校相关部门盖章的成绩单(本科两年半成绩)、申请材料中涉及的相关证明材料的电子版文件,一并发送至fengxinwei@zju.edu.cn邮箱。逾期未提交回执视作放弃参加本次夏令营;

2. 75日前将电子版结核菌测试结果发送至fengxinwei@zju.edu.cn邮箱。由于实验室属于高洁净环境,营员须进行结核菌测试,可经由皮测、胸片或血液等不同方法取得;

3. 报到时需出示身份证、学生证、外语成绩单、学校相关部门盖章的成绩单(本科两年半成绩)、申请材料中涉及的相关证明材料等原件;

4. 报到时需提交材料:单程来杭车票或飞机票(登机牌及电子行程单)。

三、营员注意事项:

1. 营员请自行提前预订往返车票,夏令营举办方不提供订票服务;

2. 夏令营活动期间营员必须听从带队老师安排,参加集体活动,不得擅自活动;

3. 差旅费报销标准:飞机、火车(含动车组列车)按实际路线的火车硬座(或二等座)票价报销,汽车按实际路线票价报销。营员报到后需全程参加夏令营活动,否则不予报销差旅费(按浙大本科生实习费用规则报销,车票信息与学校或家庭所在地乘车区间相符者有效)。

确认参营同学请加2019ZIINT入营微信群:

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附件1:2019ZIINT参营回执.xlsx

附件2:夏令营营员衣服尺码.jpg

 

2019-06-26 READ MORE
2019-06-04 READ MORE
2019-05-28 READ MORE
2018-10-11 READ MORE
2018-10-11 READ MORE

How do our brains enable us to see the many shapes of objects in the world? One idea posed by neuroscientists is that there are different types of neurons in the brain that recognize different elements of shape, such as straight lines, curves, and corners, and that shapes are the result of integrating these different basic elements. However, where these neurons are and how their information is integrated is not well understood. 


图片1.png  

  

In the late 1960s, Nobel Laureates Hubel and Wiesel discovered that the first stage of visual information processing in the cortex (primary visual cortex) contains submillimeter-sized functional units called orientation columns. They showed that each column contained neurons responsive to only a certain contour orientation (e.g. neurons in a ‘vertical’ orientation column would respond to the vertical contour of a tall tree but not to the contour of a horizontal tree branch). It was later discovered that the set of all possible orientation columns (0-180 deg) shifted systematically around a point in a ‘pinwheel-like’ fashion. This concept of a single orientation column encoding a single contour orientation has been a cornerstone of sensory systems neuroscience.


In this study, two research teams cooperated to develop a novel, highly precise method of targeting electrodes in the orientation column and accurately determinng their position, so that different regions within single orientation columns could be probed. Using intrinsic signal optical imaging to map the orientation columns, researchers conducted systematic and comprehensive study of the functional properties of neurons in different parts of individual orientation columns. For the first time, they found that within single orientation columns there is a clear distribution of neurons with different functional preferences. Specifically, they found three subdomains, whose functional responses were consistent with the encoding of straight lines, curves, and complex contours, respectively. This suggested that single orientation columns may contain multiple basic elements for building shapes and led to a new concept of the ‘pinwheel-centered orientation hypercolumn’. Thus, their technical advance has led to a new view of the orientation column and of cortical functional architecture. This new finding will also be useful for computational models of shape encoding in the brain.

 

图片2.png 

 

Online Paperhttps://advances.sciencemag.org/content/5/6/eaaw0807


2019-06-06 READ MORE

Columnar connectome: towards a mathematics of brain function

https://www.mitpressjournals.org/doi/abs/10.1162/netn_a_00088


Summary:

What makes the brain unique is its vast network of connections. It is the SYSTEMATIC PATTERNs of functional connections lead to behavior, thoughts, and feelings. This article proposes that there are common repeated patterns of connectivity and that these patterns can be represented mathematically. Such brain math opens doors to understanding biological thought, design of new targeted brain-machine interfaces, and a new generation of artificial intelligence.


Abstract

Understanding brain networks is important for many fields, including neuroscience, psychology, medicine, and artificial intelligence. To address this fundamental need, there are multiple ongoing connectome projects in the US, Europe, and Asia producing brain connection maps with resolutions at macro-, meso-, and micro-scales. This viewpoint focuses on the mesoscale connectome (the columnar connectome). Here, I summarize the need for such a connectome, a method for achieving such data rapidly on a largescale, and a proposal about how one might use such data to achieve a mathematics of brain function.

2019-05-07 READ MORE

The brain is made up of “cities” and “buildings” with different functions. Numerous neural connections are like “information roads” that connect them into a network. Based on the brain network, information is transmitted from sensory input, processed in the brain, and ultimately produces memories, emotions, and behaviors. Therefore, understanding the brain requires mastering the “brain map”, which is like having a map when people travel. However, at present, when brain scientists explore the mysteries of the brain, but there is no complete "brain traffic map" for reference.

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On April 24th, local time, the team of Anna Wang Roe, Institute of Systematic Neurology and Cognition, Zhejiang University, published a brain network study online in Science Advances. The latest breakthrough in the method. Their new technology, INS-fMRI, combines infrared light stimulation with magnetic resonance imaging for the first time. This new method allows sub-millimeter brain connections in the living brain, enabling us to be faster and more systematic. Look at the "brain traffic map" to understand the transmission of information. “It’s like, we can not only know that a package departs from a laboratory building in Zhejiang University in Hangzhou to Beijing, but also knows its destination details such as district, street, building and even floor number” Xu Guohua, the first author of the article Introduced in the interview.

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Other participants in the study included the co-first author, PhD studeng Qian Meizhen, correspondent author Dr. Zhang Xiaotong, Dr. Chen Gang and Dr. Anna Wang Roe. They developed INS-fMRI technology to study brain networks in vivo, and their characteristics can be summarized as faster, stronger, and higher.

faster

The anatomical methods used to map brain connections usually involve injecting dyes at several initial locations in the brain, taking weeks to transport the dye and "painting" the nerve connections, then sacrificing the animal to make the brain slices, and finally very time-consuming image reconstruction and analysis. Even so, only a few injection sites can be studied in an animal.

The new technology invented by this research group combines laser stimulation and magnetic resonance imaging to quickly display in three dimensions. Preliminary results can be obtained in 1-2 hours of scanning, which is very convenient for studying brain regions at the whole brain level. The degree of response can be quickly studied in a single-day experiment. Xu Guohua said: "Instead of slowly coloring the road, it is better to send a bunch of express delivery from Hangzhou. In a very short time, we can know which cities they have arrived in."

“In addition, the benefits of INS-fMRI technology are not only fast, but also facilitate the in vivo experiments, greatly reducing the number of animals used, and conducting multiple follow-up studies on the same animal, such as studying brain development,” Wang Jing The professor said.

● stronger

Stronger performance means quantifiable and more accurate.

The infrared pulse is illuminated by a 200 micron diameter fiber to the target brain region, causing a neural response in the brain region and associated brain regions. Once the signal is activated, it will cause blood oxygen changes. This blood oxygen signal can be captured by magnetic resonance imaging. "The strength of the connection can be quantified as the magnitude and correlation of the response via the blood oxygenation reaction," Xu Guohua said.

In the early years, Professor Wang Jing was inspired by the use of laser instead of current-activated neurons in cochlear implant research. She began this research and became the first scientist to introduce infrared light stimulation into brain research. The significance of this shift is about precision, the infrared light pulse delivers energy to a very small space, achieving precise stimulation and causing spatial specificity of the connected sites.

● higher

Higher performance is high resolution. When using ultra-high field (7 Tesla) magnetic resonance imaging, these response positions can be presented at sub-millimeter resolution. This provides the basis for studying the activities of the various cortical functional columns ("buildings") and the various layers of the cortex ("floors"). "We combined the infrared light stimulation method with functional magnetic resonance and proposed this experimental method for the first time in the world." Wang Jing said.

The so-called functional column is an information processing unit inside the brain, and the size is only two or three hundred micrometers. The primate brains are arranged neatly by these functional columns; each functional column happens to correspond to a specific cognitive function and is connected to each other as a network. Therefore, for primates including humans, it is especially important to map brain connections between macro and micro scales.

However, researchers currently only know that functional columns are functional units, but it is not clear how they are specifically connected. Xu Guohua explained: "It's like many tall buildings with different functions, some schools, some hospitals, etc., but we don't understand how these buildings are connecting."

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“This method can be used to systematically stimulate the cortical function column one by one to fully depict the primate mesoscopic connectome.” Wang Jing introduced that this new technology will be a whole brain network with high-resolution functional columns. The map lays the foundation and opens the door for large-scale research. By clarifying the connections between the various functional columns, it will greatly help us understand how the primate (including human) brain works and brain diseases, and will promote the development of neuroscience, psychology, medicine and artificial intelligence.

In the Science Advances article, the research team reported two application examples, corresponding to the study of long-range connections at the whole brain scale, and high-resolution short-range connections within a local range. Experiments have shown that the application of this new method will probably help us to understand the connection and working principle of the brain, and then better understand the disease and precisely regulate the related brain structure and function.

Paper link:  https://advances.sciencemag.org/content/5/4/eaau7046


2019-04-25 READ MORE


Zhejiang University Interdisciplinary Institute of Neuroscience and Technology (ZIINT, www.ziint.zju.edu.cn) seeks faculty candidates for study of cortical organization and development, using 2-photon and 3-photon instruments.  Competitive candidates will have strong optical and engineering background and a strong research program. Any of the following qualities will be considered a plus: 2-photon or multi-photon experience, optical engineering background, understanding of primate brain circuitry and/or cortical development, strong quantitative and analytical skills, and demonstrated ability to integrate multiple technologies. Faculty at ZIINT are highly interactive and participate in collaborative projects within the institute and with other departments on topics of neuroscience, brain-machine interface, medicine, and artificial intelligence. Faculty candidates at both junior or senior levels will be considered. Salary is competitive and commensurate with experience.  

Zhejiang University’s Interdisciplinary Institute of Neuroscience & Technology (ziint.zju.edu.cn/en/index.asp) is home to 15 labs, an MRI center for human and nonhuman primate research, coil making facility, nonhuman primate facility, multi-photon and high throughput microscopy, computer cluster, and viral vector core. The institute has two Bruker systems (2-photon with SLM capability and a 3-photon). ZIINT fosters an environment of exciting collaborative and interdisciplinary interaction. English is the common language; lectures and seminars are given in English. Students at ZIINT are topnotch, lead weekly journal clubs, invite international speakers, and attend international conferences. There is strong support for postdoctoral fellows. ZIINT organizes international conferences and workshops (e.g. Frontiers in Neuroscience and Technology (FINT), Asia-Pacific Symposium on Advances in Ultrahigh Field MRI).


Zhejiang University is located in Hangzhou, China, an hour by bullet train from Shanghai. Home to beautiful West Lake, Hangzhou is both a modern and a historical city, with an emphasis on culture and environment. Direct flights to Hangzhou are available from LAX, Amsterdam, and multiple cities in Asia. 


Interested candidates should send a CV, names of 3 references, and a statement of research interests to Dr. Anna Wang Roe at annawang@zju.edu.cn.

2019-08-01 READ MORE

Recruiter: A/Prof.Ruiliang Bai

Email: ruiliangbai@zju.edu.cn

Research Interests: Novel functional MRI contrasts and methods; Microstructural MRI; Metabolic imaging; CNS disease diagnosis; Stoke diagnosis

Keywords: Brain imaging; High-field MRI; MRI biophysics


A postdoctoral position to conduct ultra-high-field MRI methods development and application studies is available in ZIINT, under the supervision of both Prof.Anna Roe and A/Prof.Ruiling Bai. ZIINT features an MRI center for both human and animal work (Zhejiang University-Siemens Brain Imaging Research Center) which houses a 3T Prisma and 7T Magnetom,MR-compatible sensory stimulus presentation systems, human MR-compatible EEG system,coil making facility, and animal support equipment. 


This project will be focused on developments of MRI sequences and methods on the 7T MRI.The potential directions includes but is not limited to (1) magnetic resonance spectroscopy (MRS) and related imaging techniques;(2) advanced diffusion MRI for microstructure imaging;(3) temperature mapping;(4) high-resolution CBF and CBV imaging.Another direction would be the applications of these newly developed sequences,for example, in the diagnosis of brain disorders by collaborating with hospitals nearby. The candidate will also have the chance to combine other methodologies developed in PI's lab, including optical imaging,neurophysiology, focal brain stimulation methods (electrical, pulsed near infrared stimulation,and optogenetics stimulation).


Candidates should have a strong research background in MRI technique,especially on Siemens platform. Familiarity with Matlab and MRI physics is a plus. Candidate should have ability to work both independently and as part of a team with other neuroscientists, MR physcists, and animal care personnel.


Please send CV,research statement and names of three references to:

Email: ruiliangbai@zju.edu.cn; Salary and rank will be commensurate with experience.

Ruiliang Bai, Associated Professor

Zhejiang University Director of Zhejiang University Interdisciplinary Institute of Neuroscience and Technologe(ZIINT)


2019-05-16 READ MORE

Recruiter: Dr.Anna Wang Roe

Email: annawang@zju.edu.cn

Assistant: Ming Xiong xiongming@zju.edu.cn

Research Interest: Cerebral cortex;Visual and perceptual neural mechanisms;touch; attention and cognition;Neurotechnology.

Key Word: Optical Imaging; UHF MRI;Electrophysiology;Non-Human primate(NHP); Optical Stimulation; Behavior. 


Seeking two postdoctoral fellows for monkey connectome project at Zhejiang University.Existing connectomes have offered great advances in our understanding of brain networks.However,greater spatial resolution is needed to observe column-based functionally specific networks.We have developed a new in vivo functional tract tracing technique,combining laser stimulation and 7T fMRI with custom made multiarray coils, to achieve a columnar connectome.We seek candidates with strong (1)fMRI background, (2)computational and mathematical background,and/or (3)optical and engineering background.Any of the following will be considered a plus:fMRI experience,strong quantitative and analytical skills,familiarity with MRI analysis platform (e.g. matlab, AFNI,…),understanding of primate brain circuitry,experience with brain connectomes.Salary is competitive and commensurate with experience.

 

Zhejiang University’s Interdisciplinary Institute of Neuroscience & Technology (ziint.zju.edu.cn/en/index.asp) is home to 15 labs,an MRI center for human and nonhuman primate research,coil making facility,nonhuman primate facility,2 photon and high throughput microscopy,computer cluster,and viral vector core.We foster an environment of exciting collaborative and interdisciplinary interaction.English is the common language;lectures and seminars are given in English.

 

Zhejiang University is located in Hangzhou,China,an hour by bullet train from Shanghai.Home to beautiful West Lake, Hangzhou is both a modern and a historical city,with an emphasis on culture and environment.Direct flights to Hangzhou are available from LAX,Amsterdam,and multiple cities in Asia.

 

Interested candidates should send a CV,names of 3 references,and a statement of research interests to Dr. Anna Wang Roe at annawang@zju.edu.cn.

 

2018-09-19 READ MORE

SHARED FACILITY

  • Highfield MRI

  • Nonhuman Primate Facility

  • Two Photon Microscopy

  • High Throughput Microscopy

  • RF Coil

  • 3Dprinting and Machinng

  • Computer Cluster

  • Viral Vector Core

  • Highfield MRI

  • Nonhuman Primate Facility

  • Two Photon Microscopy

  • High Throughput Microscopy

  • RF Coil

  • 3Dprinting and Machinng

  • Computer Cluster

  • Viral Vector Core

THE TEAM

ABOUT US

Zhejiang University Interdisciplinary Institute of Neuroscience and Technology (ZIINT) was founded in 2013 by Prof. Anna Wang Roe on Huajiachi Campus. Prof. Anna Wang Roe is an internationally well-recognized scentisit in the field of neuroscience and its related interdisciplines. The ultimate goal of ZIINT is to do fundamental researches in the field of cognitive and behavioral neuroscience, to explore the neural network mechanism of brain advanced function, and to achieve major breakthroughs in brain function and brain diseases. Another goal of ZIINT is to establish links for related disciplines in fields of medicine, neuroscience, engineering and other fields, and work closely with major industries and hospitals to develop new technologies for neuroscience studies and promote our fundamental researches for clinical translation.


Currently, ZIINT has the only actively shielded 7T Ultra-High field magnetic resonance system - the "MAGNATOM 7T" in China, and a live-two-photon imaging system, and also has the top neuroscience and brain cognitive research equipment with automatic, high-throughput, high-speed fluorescence scanning systems recognized by the scientific community, moreover the institute has established 20 basic research laboratories, and is equipped with multiple public experimental platforms to support each laboratories working.


Since the establishment of ZIINT, 16 outstanding PIs have been recruited, they have good academic literacy and profound research capacity, involving a wide range of research fields. A total of 25 funding projects have been awarded by the National Science Fund for Distinguished Young Scholars, the Fund Development Committee Major Research Project Nurturing Project, the National Natural Science Foundation of China, the 973 Scientific and Technological Problem - Oriented Project of the Ministry of Science and Technology, and the National 863 Program. Since our enrollment in 2014, we have already recruited 34 doctoral students and 13 master students. At the same time, high-quality cross-disciplinary international conferences such as "Frontiers in Interdisciplinary Neuroscience and Technology" and "Asia-Pacific Symposium on Advances in UHF MRI" high-field magnetic resonance and other meetings are held each year. The sharing of research experience and technology provides an international front-line communication platform to further promote the development of the field and the exploration of new fields in cross-disciplines. At the same time, we conduct collaboration program with a number of hospitals in Hangzhou to directly promote scientific research achievements conversion.


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