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   INTERDISCIPLINARY INSTITUTE OF NEUROSCIENCE AND TECHNOLOGY

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INTERDISCIPLINARY INSTITUTE OF NEUROSCIENCE AND TECHNOLOGY

7T TEAM

    INTERDISCIPLINARY INSTITUTE OF NEUROSCIENCE AND TECHNOLOGY

MAGNETOM 7T MRI

               INTERDISCIPLINARY INSTITUTE OF NEUROSCIENCE AND TECHNOLOGY

GRADUATE SCHOOL OF ZJU

WELCOME TO JOIN US

   INTERDISCIPLINARY INSTITUTE OF NEUROSCIENCE AND TECHNOLOGY

The International Society for Magnetic Resonance in Medicine (ISMRM) is the biggest international conference in the field of medical magnetic resonance imaging (MRI). The 27th ISMRM was held on 16-21 June in Paris, France. Many teachers and students in our institute attended the conference and made oral and poster presentations. On the morning of June 21st, Dr. Guohua Xu (a.k.a Augix) gave a talk titled "A novel method for mesoscale connectome mapping: focal infrared neural stimulation in high-field functional MRI". The talk received the ISMRM Magna Cum Laude Merit Awards. In this talk, Guohua introduced the development of a new technique led by him and Prof. Anna Wang Roe. This technique is a new method for studying brain connectivity. It combines 7T ultra-high field functional MRI and near-infrared laser stimulation. The purpose of developing this technique is to rapidly and systematically study primate connectomes at sub-millimeter resolution.


Dr. Guohua Xu studied the evolution of rice genome in Zhejiang University between 2000 and 2004, and received Bachelor degree in Agronomy. He then moved to France, studied the evolution of mouse genome, and received Master degree in Biomathematics in Bioinformatics from University of Lyon 1. Between 2006 and 2010, he worked in CAS-MPG Partner Institute for Computational Biology, and led a study between human and chimpanzee brain gene expression. In 2010, he started his Ph.D. program in Max Planck Institute for Evolutionary Anthropology in Germany, and studied gene expression evolution in single cells in primate prefrontal cortices. In 2015, he joined Prof. Anna Wang Roe’s laboratory in Zhejiang University Interdisciplinary Institute of Neuroscience and Technology (ZIINT). His current research focus is the development of a new technique for connectome mapping.


2018-07-17 READ MORE

201878日,浙江大学求是高等研究院优秀大学生夏令营活动在浙大玉泉校区开营。本届夏令营面向全国高校,以参与和互动的方式让大学生们感受当前国际脑科学前沿发展态势,着重介绍浙大求是高等研究院在脑机接口和系统神经认知领域取得的研究成果。脑机接口作为神经科学、计算机技术、通信等领域的交叉技术,已得到国际上众多学科工作者的高度关注,成为当前科学界最热门最前沿的交叉研究领域之一。该技术对推动康复医学发展和探究大脑机制有着不可估量的深远意义。求高院的各位老师通过生动有趣的讲解,由浅而深地阐述了人类大脑活动机制,并发起现场互动让学生亲自体验简单的脑控实验,极大地引发了同学们的兴趣。本次活动受到各大高等院校同学们强烈反响,参与踊跃。

在夏令营开营仪式上,脑机接口实验室王跃明教授,系统神经与认知科学研究所所长、国家千人计划专家王菁(Anna Wang Roe)教授首先对营员们的到来表示欢迎,分别介绍了求是高等研究院、脑机接口实验室及系统神经与认知科学研究所的相关研究工作。营员们通过参观校园,感受了浙江大学百年来浓郁的学术气息。在聆听了求高院各位教授的专题演讲和实验室参观后,营员们得以近距离了解求是高等研究院在脑机接口和认知神经科学领域丰硕的研究成果。营员们还通过参加多种形式的师生互动和学生交流活动,激发了对科研的热情和兴趣,以及对未来专业和人生规划的广泛思考。

本次夏令营活动于11日上午圆满结束,4天的相处,促进了高校优秀大学生间的交流互动,加强了神经生物学、生物医学工程和信息电子工程等专业与国内高水平大学相关院系的联系,同时让参营学生对浙大求是高等研究院有了清晰的认识,为将来投身脑科学领域的研究奠定基础。


2018-07-17 READ MORE

  On May 24th, Professor Pasko Rakic of Yale University School of Medicine gave a brilliant lecture titled “The evolution of brain and the formation of brain map during disease development” for Zhejiang master students in the Zijingang lecture hall of Alumni House. Pasko Rakic is a renowned neuroscientist at Yale University School of Medicine and is also the recipient of the 2008 Kavli Neuroscience Award.


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  Prof Rakic is affable and lectures are humorous. He started from studies he had done before, eliciting the phenomenon that “cortical neurons are not produced within the cerebral cortex itself” and further analyzed how this phenomenon occurs and the causes behind it. Prof. Rakic also contrasted his choice-elimination hypothesis with the alternative retention hypothesis proposed by Prof. Changex, humorously comparing it to “half-full cup and half-empty cup”.

  Professor Rakic pointed out that the core issue is not the dispute between genes and environment or stability and plasticity. The focus of research should be on how the two complement and supplement each other. Subsequently, he compared and analyzed the cerebral cortex differences between rats and humans in terms of both qualitative and quantitative dimensions. At the same time, he carefully traced the cerebral cortex elements from which the monkeys were born, and analyzed the external environment differences (pressure, fever, and other Disease, etc.) The development of different degrees of brain area development. After a series of analyses, Rakic concludes that as the evolution of vertebrates evolves, neuronal turnover capacity continues to decline.


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  The atmosphere of the interactive session was enthusiastic. The students actively asked questions about the speech and the teacher also asked questions about the operation of the study. The entire lecture ended successfully in the interaction.

2018-05-25 READ MORE
2018-07-17 READ MORE

各单位:

201859日起,取消201611月发布的《关于不做固定资产相关事宜的通知》的相关条款,所有单价≥1000元的设备或设备维修配件或设备中的耗材申请不属固定资产时均须通过统一身份认证系统登录浙江大学仪器设备管理系统”选择资产业务办理中的“办理设备建账”页面里“申请不属固定资产”模块进行申报并进行财务预约。为方便师生办理业务59日至531日期间,原有现场审批办理模式和网上申报模式皆可办理,自61日起,终止原有现场审批办理模式,全部业务均需网上申报。

  申报时须上传发票,并根据实际情况阐述理由,具体要求如下:

1.选择申请理由为“维修更换配件”时需在佐证材料处上传维修单或维修协议;无法提交维修单或维修协议的照片,请在理由补充栏内说明内阐述理由。

2.选择申请理由为“使用寿命不足一年”时需在佐证材料处上传产品保修卡等证明。无法提交,请在理由补充栏内说明内阐述理由。

3.选择申请理由为“特殊情况使用,无法回收”时如无法提交佐证材料,请在理由补充栏内说明内阐述理由。

4.对于单价≥2万元(含)以上申请不属固定资产的,需上传物品照片;如果是维修更换的还需上传更换下来的旧件照片。

5.通过审批后,申请人由本系统完成财务预约,持预约单和发票递交计财处不等候报销窗口。

   请遵照执行,并相互转告。

    办理流程及审批过程参见实验室与设备处办事流程:   http://zjulab.zju.edu.cn/2018/0508/c3145a803114/page.psp

     实验室与设备管理处

     201858

2018-05-08 READ MORE
2018-05-29 READ MORE
2018-05-29 READ MORE
2018-05-29 READ MORE

Significance

Body-centered (egocentric) and world-centered (allocentric) spatial reference frames are both important for spatial navigation. We have previously shown that vestibular heading signals, which are initially coded in a head-centered reference frame, are no longer head-centered in the ventral intraparietal (VIP) area, but instead are represented in either a body- or world-centered frame, as the two frames were not dissociated. Here, we report a flexible switching between egocentric and allocentric reference frames in a subpopulation of VIP neurons, depending on gaze strategy. Other VIP neurons continue to represent heading in a body-centered reference frame despite changes in gaze strategy. These findings suggest that the vestibular representation of heading in VIP is dynamic and may be modulated by task demands.

Abstract

By systematically manipulating head position relative to the body and eye position relative to the head, previous studies have shown that vestibular tuning curves of neurons in the ventral intraparietal (VIP) area remain invariant when expressed in body-/world-centered coordinates. However, body orientation relative to the world was not manipulated; thus, an egocentric, body-centered representation could not be distinguished from an allocentric, world-centered reference frame. We manipulated the orientation of the body relative to the world such that we could distinguish whether vestibular heading signals in VIP are organized in body- or world-centered reference frames. We found a hybrid representation, depending on gaze direction. When gaze remained fixed relative to the body, the vestibular heading tuning of VIP neurons shifted systematically with body orientation, indicating an egocentric, body-centered reference frame. In contrast, when gaze remained fixed relative to the world, this representation changed to be intermediate between body- and world-centered. We conclude that the neural representation of heading in posterior parietal cortex is flexible, depending on gaze and possibly attentional demands.

Keywords

ventral intraparietal area | reference frame | vestibular |body/world-centered | egocentric/allocentric

 

Online Paper: http://www.pnas.org/content/early/2018/03/14/1715625115

Flexible egocentric and allocentric representations of heading signals in parietal cortex.pdf

Reference

[1] Chen X, DeAngelis GC, Angelaki DE (2013) Diverse spatial reference frames of vestibular signals in parietal cortex. Neuron 80:1310-1321.

 

2018-03-27 READ MORE

In a recent study published in Cerebral Cortex entitled “Presynaptic GABAa Receptors Modulate Thalamocortical Inputs in Layer 4 of Rat V1”, Dr. Lang Wang and her colleagues reported an exciting existence of presynaptic GABAa receptors selectively expressed on thalamocortical axon terminals by combining electrophysiology, optogenetic and EM approaches, which provides a novel mechanistic insight into the effects of changes in cortical inhibition and the ability to modulate inputs onto cortical circuits locally via presynaptic GABAa receptors.

 

Neocortical GABAergic neurons are diverse and connect broadly to excitatory neurons, providing cortical circuits with sophisticated computational control of neuronal activity. While there is general agreement regarding the involvement of fast GABAa receptor-mediated inhibition in the control of circuit excitability, several unresolved issues remain concerning how this regulation is achieved. The current thinking is that GABAa receptors are located mainly at postsynaptic and extrasynaptic sites in neocortex, thus manipulation of fast inhibition would only affect intracortical circuits, while leaving incoming afferent inputs unaffected. Here we report that GABAa receptors containing specific subunits are selectively present on presynaptic terminals of thalamocortical (TC) inputs in L4, the main input layer of primary visual cortex (V1), which can be activated in response to GABA release by local high frequency firing of inhibitory neurons, thus decreases neurotransmitter release and modulates short-term plasticity. These results suggest an important role for presynaptic GABAa receptors on TC synapses in regulating local circuit excitability, gating TC information to V1, and providing a novel mechanism for local corticothalamic feedback.

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Below is the link to access the article: https://www.ncbi.nlm.nih.gov/pubmed/29373653

Presynaptic GABAA Receptors Modulate Thalamocortical Inputs in Layer 4 of Rat V1.pdf


2018-03-14 READ MORE

In March 2018, IEEE Transactions on Medical Imaging published a full research paper from Dr. Xiaotong Zhang’s group, titled “Investigating the Influence of Spatial Constraints on Ultimate Receive Coil Performance for Monkey Brain MRI at 7T”. Ph.D. candidate Yang Gao is the first author.

The RF receive coil array has become increasingly vital in current MR imaging practice due to its extended spatial coverage, maintained high SNR, and improved capability of accelerating data acquisition. In this study, seven hypothetical ultimate coil arrays with different coil-space configurations were mounted over a numerical macaque head model (as shown below), and the influences of coil-space design parameters were systematically investigated through evaluating the spatial constrained ultimate intrinsic SNR (UISNR) and ultimate g-factor (uGF); moreover, simulations were also conducted by using four coil arrays with limited number of loop-only elements, in order to explore to what extent, the ultimate coil performance can be achieved by using practical coil designs, and hence several guidelines in RF coil design for monkey brain imaging at 7T have been tentatively concluded. It is believed that the present analysis will offer important implications in novel receive array design for monkey brain MR imaging at UHF.

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Online Paperhttp://ieeexplore.ieee.org/document/8307466/

Investigating the Influence of Spatial Constraints on Ultimate Receive Coil Performance for Monkey Brain MRI at 7T

2018-03-09 READ MORE

脑科技领域是国家科技发展战略中的重点方向,为了进一步推动脑科学研究与脑机融合技术的科技创新,培养理、工、医等多学科交叉的跨领域人才,浙江大学求是高等研究─系统神经与认知科学研究所【赖欣怡教授课题组】,特面向海内外公开招聘博士后2-3名,竭诚欢迎海内外精英加盟。

浙江大学系统神经与认知科学研究所成立于2013年,主要目标为解决认知与行为神经科学领域的重大问题,探索脑高级功能的神经网络机制,在脑功能和脑疾病等相关研究中取得重大突破;为相关医学、神经科学、工程学以及其他领域交叉学科的沟通搭建了桥梁;同时致力于跨学科研究,将与各大医院紧密合作,使科研成果产业化,真正的推动神经医学的发展。

赖欣怡课题组致力于发展先进的神经工程技术,通过生医微机电技术、超高场磁共振成像技术、神经调控技术、计算神经科学的多学科交叉整合创新,开发脑科学研究及脑疾病诊治需要的关键技术,主要研究:(1)神经调控技术:发展磁兼容聚焦超声及脑深部电刺激技术应用于脑功能与神经精神疾病的研究;(2)脑机接口:研究(非人)灵长类触动觉神经编码机制;(3)生医微机电芯片传感器:采用生医微机电技术开发具复合功能的神经探针与生医微芯片系统。近三年已获3项国家自然科学基金(主持2项、子课题负责人1项)、1项科技部国家重点研发计划(骨干)、2项中央高校科研经费(主持1项、共同主持1项),及1项省级大科学装置研制项目(子课题负责人1项)等资助。

 

【应聘人员基本条件】

1、已取得工程学、生物学、医学或药学等相关专业博士学位。

2、良好的独立科研能力及科学素养、富有责任感和团队协作精神。

3、良好的英文阅读、写作和口头交流能力。

4、年龄35周岁以下,身体健康。

5、以下背景经验者优先考虑:

(1)动物脑手术实验经验。

(2)结构与功能核磁共振影像分析。

(3)神经电生理数据分析及神经信息编码与解码模型。

(4)良好的编程能力,熟悉Matlab、C或R语言。

(5)生医微机电制程及芯片设计经验。

【工作待遇】

    工资及福利待遇按国家博士后相关规定执行,年薪一般15 - 20万元人民币;优秀博士可申请浙江大学国际交流计划引进项目,获批年薪可达30万元人民币;提供教师公寓(优惠价租赁)

 

【需提供的材料】

申请者通过电子邮件,邮件主题请注明:“博士后应聘_姓名”,提供如下材料:

1、个人简历(包括一般情况、受教育经历、工作经历、专业技能及特长、各类研究项目、各类发表论文、各类奖励等);

2、2~5篇代表性论文的PDF全文版;

3、研究兴趣及受聘后的工作设想和目标。

 

【联系方式】

赖欣怡教授

联系邮箱:laihy@zju.edu.cn

2018-05-03 READ MORE

A postdoctoral position to conduct ultra-high-field MRI methods development and application studies is available in ZIINT (http://www.ziint.zju.edu.cn/index.php/Index/index.html), under the supervision of both Prof. Anna Roe and Prof. Ruiling Bai. ZIINT features an MRI center for both human and animal work (Zhejiang University-Siemens Brain Imaging Research Center) which houses a 3T Prisma and 7T Magnetom, MR-compatible sensory stimulus presentation systems, human  MR-compatible EEG system, coil making facility, and animal support equipment. 

 

This project will be focused on developments of MRI sequences and methods on the 7T MRI. The potential directions includes but is not limited to (1) magnetic resonance spectroscopy (MRS) and related imaging techniques; (2) advanced diffusion MRI for microstructure imaging; (3) temperature mapping; (4) high-resolution CBF and CBV imaging. Another direction would be the applications of these newly developed sequences, for example, in the diagnosis of brain disorders by collaborating with hospitals nearby. The candidate will also have the chance to combine other methodologies developed in PI's lab, including optical imaging, neurophysiology, focal brain stimulation methods (electrical, pulsed near infrared stimulation, and optogenetics stimulation).

Candidates should have a strong research background in MRI technique, especially on Siemens platform. Familiarity with Matlab and MRI physics is a plus. Candidate should have ability to work both independently and as part of a team with other neuroscientists, MR physcists, and animal care personnel.

Please send CV, research statement and names of three references to:
Email: ruiliangbai@zju.edu.cn; Salary and rank will be commensurate with experience.

 

Ruiliang Bai,  Associated Professor

Zhejiang University Director of Zhejiang University Interdisciplinary Institute of  Neuroscience and Technologe


2018-04-23 READ MORE

根据课题组科研工作需要,浙江大学求是高等研究院系统神经与认知科学研究所高利霞课题组“听觉的感知与认知实验室”拟公开招聘博士后1-2名。招聘坚持公开、公平、竞争、择优的原则,经资格审核后,组织面试考核。一经录用,待遇从优,年薪18万元起。

 

一、课题组研究方向

本课题组主要以灵长类动物狨猴为研究对象,采用电生理学、行为学和分子生物学方法研究:

1. 自然界声音、语言和音乐等复杂声在大脑的神经编码和环路机制;

2. 狨猴叫声的发育过程;

3. 人类神经精神系统疾病,如自闭症,在狨猴的建模和神经环路机制研究。

更多详情可见本课题组网页:http://www.ziint.zju.edu.cn/index.php/Index/zindex.html?tid=0&userid=16

 

二、岗位要求

1. 具有热爱学习、积极进取的态度;

2. 具有独立的科研能力,能够独立思考和解决具体实验问题;

3. 近年获得相关领域博士学位,年龄不超过35岁;

4. 具有神经科学、医学、生物医学工程、心理学、计算机和数学等相关专业背景者优先;

5. 熟悉分子生物学和在体电生理记录者优先。

 

三、联系方式

有意者请将本人简历、博士学位证书扫描件和求职信发送至sunhao@zju.edu.cn(孙昊收),邮件主题请注明“姓名+毕业院校+博士后应聘”,正文表明本人求职意向,并重点介绍本人的科研经历和专业技能及特长。符合要求者,我们将尽快安排面试。


2018-03-13 READ MORE

SHARED FACILITY

  • Highfield MRI

  • Nonhuman Primate Facility

  • Two Photon Microscopy

  • High Throughput Microscopy

  • RF Coil

  • 3Dprinting and Machinng

  • Computer Cluster

  • Viral Vector Core

  • Highfield MRI

  • Nonhuman Primate Facility

  • Two Photon Microscopy

  • High Throughput Microscopy

  • RF Coil

  • 3Dprinting and Machinng

  • Computer Cluster

  • Viral Vector Core

THE TEAM

ABOUT US

Zhejiang University Interdisciplinary Institute of Neuroscience and Technology (ZIINT) was founded in 2013 by Prof. Anna Wang Roe on Huajiachi Campus. Prof. Anna Wang Roe is an internationally well-recognized scentisit in the field of neuroscience and its related interdisciplines, and has been elected as the "The Recruitment Program of Global Experts (National 1000 Talents Program)". The ultimate goal of ZIINT is to do fundamental researches in the field of cognitive and behavioral neuroscience, to explore the neural network mechanism of brain advanced function, and to achieve major breakthroughs in brain function and brain diseases. Another goal of ZIINT is to establish links for related disciplines in fields of medicine, neuroscience, engineering and other fields, and work closely with major industries and hospitals to develop new technologies for neuroscience studies and promote our fundamental researches for clinical translation.


Currently, ZIINT has the only actively shielded 7T Ultra-High field magnetic resonance system - the "MAGNATOM 7T" in China, and a live-two-photon imaging system, and also has the top neuroscience and brain cognitive research equipment with automatic, high-throughput, high-speed fluorescence scanning systems recognized by the scientific community, moreover the institute has established 20 basic research laboratories, and is equipped with multiple public experimental platforms to support each laboratories working.


Since the establishment of the institute, 16 outstanding PIs have been recruited, including one of the "The Recruitment Program of Global Experts (National 1000 Talents Program)", the "Young overseas high-level talents introduction plan (National Young 1000 Talents Program)" and "Distinguished Young Scholars of China", two electees of Zhejiang Provincial "The Recruitment Program of Global Experts (National 1000 Talents Program)", and one of Zhejiang Provincial "1000 Talents Project of Foreign Experts"; one "Qiushi Jiangzuo professor" and ten adjunct professors are appointed.


A total of 25 funding projects have been awarded by the National Science Fund for Distinguished Young Scholars, the Fund Development Committee Major Research Project Nurturing Project, the National Natural Science Foundation of China, the 973 Scientific and Technological Problem - Oriented Project of the Ministry of Science and Technology, and the National 863 Program. Since our enrollment in 2014, we have already recruited 34 doctoral students and 13 master students. At the same time, high-quality cross-disciplinary international conferences such as "Frontiers in Interdisciplinary Neuroscience and Technology" and "Asia-Pacific Symposium on Advances in UHF MRI" high-field magnetic resonance and other meetings are held each year. The sharing of research experience and technology provides an international front-line communication platform to further promote the development of the field and the exploration of new fields in cross-disciplines. At the same time, we conduct collaboration program with a number of hospitals in Hangzhou to directly promote scientific research achievements conversion.


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