The International Society for Magnetic Resonance in Medicine (ISMRM) is the biggest international conference in the field of medical magnetic resonance imaging (MRI). The 27th ISMRM was held on 16-21 June in Paris, France. Many teachers and students in our institute attended the conference and made oral and poster presentations. On the morning of June 21st, Dr. Guohua Xu (a.k.a Augix) gave a talk titled "A novel method for mesoscale connectome mapping: focal infrared neural stimulation in high-field functional MRI". The talk received the ISMRM Magna Cum Laude Merit Awards. In this talk, Guohua introduced the development of a new technique led by him and Prof. Anna Wang Roe. This technique is a new method for studying brain connectivity. It combines 7T ultra-high field functional MRI and near-infrared laser stimulation. The purpose of developing this technique is to rapidly and systematically study primate connectomes at sub-millimeter resolution.

Dr. Guohua Xu studied the evolution of rice genome in Zhejiang University between 2000 and 2004, and received Bachelor degree in Agronomy. He then moved to France, studied the evolution of mouse genome, and received Master degree in Biomathematics in Bioinformatics from University of Lyon 1. Between 2006 and 2010, he worked in CAS-MPG Partner Institute for Computational Biology, and led a study between human and chimpanzee brain gene expression. In 2010, he started his Ph.D. program in Max Planck Institute for Evolutionary Anthropology in Germany, and studied gene expression evolution in single cells in primate prefrontal cortices. In 2015, he joined Prof. Anna Wang Roe’s laboratory in Zhejiang University Interdisciplinary Institute of Neuroscience and Technology (ZIINT). His current research focus is the development of a new technique for connectome mapping.

2018-07-17 READ MORE


在夏令营开营仪式上,脑机接口实验室王跃明教授,系统神经与认知科学研究所所长、国家千人计划专家王菁(Anna Wang Roe)教授首先对营员们的到来表示欢迎,分别介绍了求是高等研究院、脑机接口实验室及系统神经与认知科学研究所的相关研究工作。营员们通过参观校园,感受了浙江大学百年来浓郁的学术气息。在聆听了求高院各位教授的专题演讲和实验室参观后,营员们得以近距离了解求是高等研究院在脑机接口和认知神经科学领域丰硕的研究成果。营员们还通过参加多种形式的师生互动和学生交流活动,激发了对科研的热情和兴趣,以及对未来专业和人生规划的广泛思考。


2018-07-17 READ MORE

  On May 24th, Professor Pasko Rakic of Yale University School of Medicine gave a brilliant lecture titled “The evolution of brain and the formation of brain map during disease development” for Zhejiang master students in the Zijingang lecture hall of Alumni House. Pasko Rakic is a renowned neuroscientist at Yale University School of Medicine and is also the recipient of the 2008 Kavli Neuroscience Award.


  Prof Rakic is affable and lectures are humorous. He started from studies he had done before, eliciting the phenomenon that “cortical neurons are not produced within the cerebral cortex itself” and further analyzed how this phenomenon occurs and the causes behind it. Prof. Rakic also contrasted his choice-elimination hypothesis with the alternative retention hypothesis proposed by Prof. Changex, humorously comparing it to “half-full cup and half-empty cup”.

  Professor Rakic pointed out that the core issue is not the dispute between genes and environment or stability and plasticity. The focus of research should be on how the two complement and supplement each other. Subsequently, he compared and analyzed the cerebral cortex differences between rats and humans in terms of both qualitative and quantitative dimensions. At the same time, he carefully traced the cerebral cortex elements from which the monkeys were born, and analyzed the external environment differences (pressure, fever, and other Disease, etc.) The development of different degrees of brain area development. After a series of analyses, Rakic concludes that as the evolution of vertebrates evolves, neuronal turnover capacity continues to decline.


  The atmosphere of the interactive session was enthusiastic. The students actively asked questions about the speech and the teacher also asked questions about the operation of the study. The entire lecture ended successfully in the interaction.

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Body-centered (egocentric) and world-centered (allocentric) spatial reference frames are both important for spatial navigation. We have previously shown that vestibular heading signals, which are initially coded in a head-centered reference frame, are no longer head-centered in the ventral intraparietal (VIP) area, but instead are represented in either a body- or world-centered frame, as the two frames were not dissociated. Here, we report a flexible switching between egocentric and allocentric reference frames in a subpopulation of VIP neurons, depending on gaze strategy. Other VIP neurons continue to represent heading in a body-centered reference frame despite changes in gaze strategy. These findings suggest that the vestibular representation of heading in VIP is dynamic and may be modulated by task demands.


By systematically manipulating head position relative to the body and eye position relative to the head, previous studies have shown that vestibular tuning curves of neurons in the ventral intraparietal (VIP) area remain invariant when expressed in body-/world-centered coordinates. However, body orientation relative to the world was not manipulated; thus, an egocentric, body-centered representation could not be distinguished from an allocentric, world-centered reference frame. We manipulated the orientation of the body relative to the world such that we could distinguish whether vestibular heading signals in VIP are organized in body- or world-centered reference frames. We found a hybrid representation, depending on gaze direction. When gaze remained fixed relative to the body, the vestibular heading tuning of VIP neurons shifted systematically with body orientation, indicating an egocentric, body-centered reference frame. In contrast, when gaze remained fixed relative to the world, this representation changed to be intermediate between body- and world-centered. We conclude that the neural representation of heading in posterior parietal cortex is flexible, depending on gaze and possibly attentional demands.


ventral intraparietal area | reference frame | vestibular |body/world-centered | egocentric/allocentric


Online Paper:

Flexible egocentric and allocentric representations of heading signals in parietal cortex.pdf


[1] Chen X, DeAngelis GC, Angelaki DE (2013) Diverse spatial reference frames of vestibular signals in parietal cortex. Neuron 80:1310-1321.


2018-03-27 READ MORE

In a recent study published in Cerebral Cortex entitled “Presynaptic GABAa Receptors Modulate Thalamocortical Inputs in Layer 4 of Rat V1”, Dr. Lang Wang and her colleagues reported an exciting existence of presynaptic GABAa receptors selectively expressed on thalamocortical axon terminals by combining electrophysiology, optogenetic and EM approaches, which provides a novel mechanistic insight into the effects of changes in cortical inhibition and the ability to modulate inputs onto cortical circuits locally via presynaptic GABAa receptors.


Neocortical GABAergic neurons are diverse and connect broadly to excitatory neurons, providing cortical circuits with sophisticated computational control of neuronal activity. While there is general agreement regarding the involvement of fast GABAa receptor-mediated inhibition in the control of circuit excitability, several unresolved issues remain concerning how this regulation is achieved. The current thinking is that GABAa receptors are located mainly at postsynaptic and extrasynaptic sites in neocortex, thus manipulation of fast inhibition would only affect intracortical circuits, while leaving incoming afferent inputs unaffected. Here we report that GABAa receptors containing specific subunits are selectively present on presynaptic terminals of thalamocortical (TC) inputs in L4, the main input layer of primary visual cortex (V1), which can be activated in response to GABA release by local high frequency firing of inhibitory neurons, thus decreases neurotransmitter release and modulates short-term plasticity. These results suggest an important role for presynaptic GABAa receptors on TC synapses in regulating local circuit excitability, gating TC information to V1, and providing a novel mechanism for local corticothalamic feedback.


Below is the link to access the article:

Presynaptic GABAA Receptors Modulate Thalamocortical Inputs in Layer 4 of Rat V1.pdf

2018-03-14 READ MORE

In March 2018, IEEE Transactions on Medical Imaging published a full research paper from Dr. Xiaotong Zhang’s group, titled “Investigating the Influence of Spatial Constraints on Ultimate Receive Coil Performance for Monkey Brain MRI at 7T”. Ph.D. candidate Yang Gao is the first author.

The RF receive coil array has become increasingly vital in current MR imaging practice due to its extended spatial coverage, maintained high SNR, and improved capability of accelerating data acquisition. In this study, seven hypothetical ultimate coil arrays with different coil-space configurations were mounted over a numerical macaque head model (as shown below), and the influences of coil-space design parameters were systematically investigated through evaluating the spatial constrained ultimate intrinsic SNR (UISNR) and ultimate g-factor (uGF); moreover, simulations were also conducted by using four coil arrays with limited number of loop-only elements, in order to explore to what extent, the ultimate coil performance can be achieved by using practical coil designs, and hence several guidelines in RF coil design for monkey brain imaging at 7T have been tentatively concluded. It is believed that the present analysis will offer important implications in novel receive array design for monkey brain MR imaging at UHF.


Online Paper

Investigating the Influence of Spatial Constraints on Ultimate Receive Coil Performance for Monkey Brain MRI at 7T

2018-03-09 READ MORE

















    工资及福利待遇按国家博士后相关规定执行,年薪一般15 - 20万元人民币;优秀博士可申请浙江大学国际交流计划引进项目,获批年薪可达30万元人民币;提供教师公寓(优惠价租赁)











2018-05-03 READ MORE

A postdoctoral position to conduct ultra-high-field MRI methods development and application studies is available in ZIINT (, under the supervision of both Prof. Anna Roe and Prof. Ruiling Bai. ZIINT features an MRI center for both human and animal work (Zhejiang University-Siemens Brain Imaging Research Center) which houses a 3T Prisma and 7T Magnetom, MR-compatible sensory stimulus presentation systems, human  MR-compatible EEG system, coil making facility, and animal support equipment. 


This project will be focused on developments of MRI sequences and methods on the 7T MRI. The potential directions includes but is not limited to (1) magnetic resonance spectroscopy (MRS) and related imaging techniques; (2) advanced diffusion MRI for microstructure imaging; (3) temperature mapping; (4) high-resolution CBF and CBV imaging. Another direction would be the applications of these newly developed sequences, for example, in the diagnosis of brain disorders by collaborating with hospitals nearby. The candidate will also have the chance to combine other methodologies developed in PI's lab, including optical imaging, neurophysiology, focal brain stimulation methods (electrical, pulsed near infrared stimulation, and optogenetics stimulation).

Candidates should have a strong research background in MRI technique, especially on Siemens platform. Familiarity with Matlab and MRI physics is a plus. Candidate should have ability to work both independently and as part of a team with other neuroscientists, MR physcists, and animal care personnel.

Please send CV, research statement and names of three references to:
Email:; Salary and rank will be commensurate with experience.


Ruiliang Bai,  Associated Professor

Zhejiang University Director of Zhejiang University Interdisciplinary Institute of  Neuroscience and Technologe

2018-04-23 READ MORE





1. 自然界声音、语言和音乐等复杂声在大脑的神经编码和环路机制;

2. 狨猴叫声的发育过程;

3. 人类神经精神系统疾病,如自闭症,在狨猴的建模和神经环路机制研究。




1. 具有热爱学习、积极进取的态度;

2. 具有独立的科研能力,能够独立思考和解决具体实验问题;

3. 近年获得相关领域博士学位,年龄不超过35岁;

4. 具有神经科学、医学、生物医学工程、心理学、计算机和数学等相关专业背景者优先;

5. 熟悉分子生物学和在体电生理记录者优先。




2018-03-13 READ MORE


  • Highfield MRI

  • Nonhuman Primate Facility

  • Two Photon Microscopy

  • High Throughput Microscopy

  • RF Coil

  • 3Dprinting and Machinng

  • Computer Cluster

  • Viral Vector Core

  • Highfield MRI

  • Nonhuman Primate Facility

  • Two Photon Microscopy

  • High Throughput Microscopy

  • RF Coil

  • 3Dprinting and Machinng

  • Computer Cluster

  • Viral Vector Core



Zhejiang University Interdisciplinary Institute of Neuroscience and Technology (ZIINT) was founded in 2013 by Prof. Anna Wang Roe on Huajiachi Campus. Prof. Anna Wang Roe is an internationally well-recognized scentisit in the field of neuroscience and its related interdisciplines, and has been elected as the "The Recruitment Program of Global Experts (National 1000 Talents Program)". The ultimate goal of ZIINT is to do fundamental researches in the field of cognitive and behavioral neuroscience, to explore the neural network mechanism of brain advanced function, and to achieve major breakthroughs in brain function and brain diseases. Another goal of ZIINT is to establish links for related disciplines in fields of medicine, neuroscience, engineering and other fields, and work closely with major industries and hospitals to develop new technologies for neuroscience studies and promote our fundamental researches for clinical translation.

Currently, ZIINT has the only actively shielded 7T Ultra-High field magnetic resonance system - the "MAGNATOM 7T" in China, and a live-two-photon imaging system, and also has the top neuroscience and brain cognitive research equipment with automatic, high-throughput, high-speed fluorescence scanning systems recognized by the scientific community, moreover the institute has established 20 basic research laboratories, and is equipped with multiple public experimental platforms to support each laboratories working.

Since the establishment of the institute, 16 outstanding PIs have been recruited, including one of the "The Recruitment Program of Global Experts (National 1000 Talents Program)", the "Young overseas high-level talents introduction plan (National Young 1000 Talents Program)" and "Distinguished Young Scholars of China", two electees of Zhejiang Provincial "The Recruitment Program of Global Experts (National 1000 Talents Program)", and one of Zhejiang Provincial "1000 Talents Project of Foreign Experts"; one "Qiushi Jiangzuo professor" and ten adjunct professors are appointed.

A total of 25 funding projects have been awarded by the National Science Fund for Distinguished Young Scholars, the Fund Development Committee Major Research Project Nurturing Project, the National Natural Science Foundation of China, the 973 Scientific and Technological Problem - Oriented Project of the Ministry of Science and Technology, and the National 863 Program. Since our enrollment in 2014, we have already recruited 34 doctoral students and 13 master students. At the same time, high-quality cross-disciplinary international conferences such as "Frontiers in Interdisciplinary Neuroscience and Technology" and "Asia-Pacific Symposium on Advances in UHF MRI" high-field magnetic resonance and other meetings are held each year. The sharing of research experience and technology provides an international front-line communication platform to further promote the development of the field and the exploration of new fields in cross-disciplines. At the same time, we conduct collaboration program with a number of hospitals in Hangzhou to directly promote scientific research achievements conversion.


System neural and cognitive science research institutereturn


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