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INTERDISCIPLINARY INSTITUTE OF NEUROSCIENCE AND TECHNOLOGY

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    INTERDISCIPLINARY INSTITUTE OF NEUROSCIENCE AND TECHNOLOGY

MAGNETOM 7T MRI

               INTERDISCIPLINARY INSTITUTE OF NEUROSCIENCE AND TECHNOLOGY

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WELCOME TO JOIN US

   INTERDISCIPLINARY INSTITUTE OF NEUROSCIENCE AND TECHNOLOGY

Brain active transmembrane water cycling measured by MR is associated with neuronal activity(2018). DOI: 10.1002/mrm.27473CV.pdf


Ruiliang Bai,Charles S. Springer Jr.,Dietmar Plenz, Peter J. Basser

 

Significance

We found that neurons absorb and release water when they relay messages throughout the brain. Tracking this water movement with imaging technology may one day provide valuable information on normal brain activity, as well as how injury or disease affect brain function.

Current functional magnetic resonance imaging (fMRI) technologies measure neuronal activity indirectly by tracking changes in blood flow and blood oxygen levels. Neurons communicate with each other by a process known as firing. In this process, they emit a slight electrical charge as an enzyme moves positively charged molecules — potassium and sodium ions — through the cell membrane. In the current study, when we stimulated cell cultures of rat neurons to fire, we found that the exchanges of potassium and sodium ions was accompanied by an increase in the number of water molecules moving into and out of the cell.

We noted that our method works only in cultures of neurons and additional studies are necessary to advance the technology so that it can be used to monitor neuronal firing in living organisms.

Abstract

Purpose: fMRI is widely used to study brain activity. Unfortunately, conventional fMRI methods assess neuronal activity only indirectly, through hemodynamic coupling. Here, we show that active, steadystate transmembrane water cycling (AWC) could serve as a basis for a potential fMRI mechanism for direct neuronal activity detection.

Methods: AWC and neuronal actitivity in rat organotypic cortical cultures were simultaneously measured with a hybrid MRfluorescence system. Perfusion with a paramagnetic MRI contrast agent, Gadoteridol, allows NMR determination of the kinetics of transcytolemmal water exchange. Changes in intracellular calcium concentration, [Cai2+] were used as a proxy of neuronal activity and were monitored by fluorescence imaging.

Results: When we alter neuronal activity by titrating with extracellular [K+] near the normal value, we see an AWC response resembling Na+K+ATPase (NKA) MichaelisMenten behavior. When we treat with the voltagegated sodium channel inhibitor, or with an excitatory postsynaptic inhibitor cocktail, we see AWC decrease by up to 71%. AWC was found also to be positively correlated with the basal level of spontaneous activity, which varies in different cultures.

Conclusions: These results suggest that AWC is associated with neuronal activity and NKA activity is a major contributor in coupling AWC to neuronal activity. Although AWC comprises steadystate, homeostatic transmembrane water exchange, our analysis also yields a simultaneous measure of the average cell volume, which reports any slower net transmembrane water transport.

Keywords

active, fMRI, functional MRI, membrane, transcytolemmal, Na+/K+ ATPase, neuronal activity, pump, water exchange

Online Paper: https://doi.org/10.1002/mrm.27473

2018-10-18 READ MORE

Functionally specific optogenetic modulation in primate visual cortex

Mykyta M. Chernov, Robert M. Friedman, Gang Chen, Gene R. Stoner, and Anna Wang Roe/ PNAS October 9, 2018 115 (41) 10505-10510; published ahead of print September 26, 2018 https://doi.org/10.1073/pnas.1802018115 

 

Significance

Primate visual cortex is organized into columns that process different features of a visual scene, such as color, orientation preference, and ocular dominance. Until now, their small size has made it difficult to modulate them directly. Here, we report for the first time that focal targeting of light-sensitive ion channels (channelrhodopsins) in macaques using lentiviral vectors allows one to stimulate functional domains. We show that such targeted stimulation leads to selective activation of anatomically connected neighboring domains with similar function. Such a fine-scale optical stimulation approach is capable of mapping functionally specific domain-based neuronal networks. Its potential for linking such networks to optogenetic modulation of perception and behavior opens doors for developing targeted, domain-based neuroprosthetics.

Abstract

In primates, visual perception is mediated by brain circuits composed of submillimeter nodes linked together in specific networks that process different types of information, such as eye specificity and contour orientation. We hypothesized that optogenetic stimulation targeted to cortical nodes could selectively activate such cortical networks. We used viral transfection methods to confer light sensitivity to neurons in monkey primary visual cortex. Using intrinsic signal optical imaging and single-unit electrophysiology to assess effects of targeted optogenetic stimulation, we found that (i) optogenetic stimulation of single ocular dominance columns (eye-specific nodes) revealed preferential activation of nearby same-eye columns but not opposite-eye columns, and (ii) optogenetic stimulation of single orientation domains increased visual response of matching orientation domains and relatively suppressed nonmatching orientation selectivity. These findings demonstrate that optical stimulation of single nodes leads to modulation of functionally specific cortical networks related to underlying neural architecture.

Link: http://www.pnas.org/content/115/41/10505

2018-10-18 READ MORE


Significance

Detection and analyzing visual motion is an important task for the visual system. In the past half a century, research on motion information processing has been focused primarily on the dorsal visual areas (e.g. area MT/V5). Other visual areas (e.g. V2, V4) are virtually unexplored in this aspect, despite the fact that the motion-sensitive neurons in these areas are significantly present and form functional domains. In this study, we combined optical imaging with single-cell recordings to specifically record from direction-selective neurons in the second largest visual area, V2, in macaque monkeys, in order to have a full picture of how motion information is analyzed in the brain.

We found that motion-sensitive neurons in area V2 have characteristic features that are different from those in the well-studied motion areas like area MT. Particularly, these neurons have small receptive field and strong surround suppression, which make them sensitive to “motion contrast”, a key information delineating object boundaries. These features suggest that area V2 detects visual objects based on motion information.

Abstract

In the primate visual system, direction-selective (DS)neurons are critical for visual motion perception. While DS neurons in the dorsal visual pathway have been well characterized, the response properties of DS neurons in other major visual areas are largely unexplored. Recent optical imaging studies in monkey visual cortex area 2 (V2) revealed clusters of DS neurons. This imaging method facilitates targeted recordings from these neurons. Using optical imaging and single-cell recording, we characterized detailed response properties of DS neurons in macaque V2. Compared with DS neurons in the dorsal areas (e.g., middle temporal area [MT]), V2 DS neurons have a smaller receptive field and a stronger antagonistic surround. They do not code speed or plaid motion but are sensitive to motion contrast. Our results suggest that V2 DS neurons play an important role in figure-ground segregation. The clusters of V2 DS neurons are likely specialized functional systems for detecting motion contrast. 

Keywords

Macaque, V2, direction selectivity, RF surround, motion contrast

Online paper: https://www.cell.com/cell-reports/fulltext/S2211-1247(18)31444-X#secsectitle0265pdf.pdf

2018-10-17 READ MORE

各学院(系),行政各部门,各校区管委会,直属各单位:

根据《国务院办公厅关于2018年部分节假日安排的通知》(国办发明电〔2017〕12号),结合学校校历安排,经学校研究决定,2018年元旦、清明节、劳动节、端午节、中秋节和国庆节放假安排如下:


一、元旦:1月1日放假,与2017年12月30日(星期六)、12月31日(星期日)连休,共3天。


二、清明节:4月5日至7日放假调休,共3天。4月8日(星期日)上班、上课。


三、劳动节:4月29日至5月1日放假调休,4月28日(星期六)上班、上课。


四、端午节:6月18日放假,与6月16日(星期六)、6月17日(星期日)连休,共3天。


五、中秋节:9月24日放假,与9月22日(星期六)、9月23日(星期日)连休,共3天。


六、国庆节:10月1日至7日放假调休,共7天。9月29日(星期六)、9月30(星期日)上班。


节假日具体课程调整安排见本科生院、研究生院通知。

学校在节假日期间安排总值班,请各校区管委会安排好本校区值班,加强安全保卫工作,确保全校师生度过一个平安的节日。请各校区管委会汇总本校区各单位值班联系人及联系方式后于放假日5日前报校长办公室(传真:88981358,电子邮箱:zdlb@zju.edu.cn)。

学校总值班地点:紫金港校区纳米楼511B室;

值班时间:上午8:30—11:30,下午1:30—4:30;

值班电话:88981583(值班时间),88206110(其它时间)。


  


  


                                                                   浙江大学校长办公室


                                                                   2017年12月6日


通知链接:

http://zy.zju.edu.cn/web/detail.doappdomain=zhedasousuo&keyword=%E8%8A%82%E5%81%87%E6%97%A5&docNo=3bz22548

 


2018-09-26 READ MORE
2018-07-17 READ MORE

各单位:

201859日起,取消201611月发布的《关于不做固定资产相关事宜的通知》的相关条款,所有单价≥1000元的设备或设备维修配件或设备中的耗材申请不属固定资产时均须通过统一身份认证系统登录浙江大学仪器设备管理系统”选择资产业务办理中的“办理设备建账”页面里“申请不属固定资产”模块进行申报并进行财务预约。为方便师生办理业务59日至531日期间,原有现场审批办理模式和网上申报模式皆可办理,自61日起,终止原有现场审批办理模式,全部业务均需网上申报。

  申报时须上传发票,并根据实际情况阐述理由,具体要求如下:

1.选择申请理由为“维修更换配件”时需在佐证材料处上传维修单或维修协议;无法提交维修单或维修协议的照片,请在理由补充栏内说明内阐述理由。

2.选择申请理由为“使用寿命不足一年”时需在佐证材料处上传产品保修卡等证明。无法提交,请在理由补充栏内说明内阐述理由。

3.选择申请理由为“特殊情况使用,无法回收”时如无法提交佐证材料,请在理由补充栏内说明内阐述理由。

4.对于单价≥2万元(含)以上申请不属固定资产的,需上传物品照片;如果是维修更换的还需上传更换下来的旧件照片。

5.通过审批后,申请人由本系统完成财务预约,持预约单和发票递交计财处不等候报销窗口。

   请遵照执行,并相互转告。

    办理流程及审批过程参见实验室与设备处办事流程:   http://zjulab.zju.edu.cn/2018/0508/c3145a803114/page.psp

     实验室与设备管理处

     201858

2018-05-08 READ MORE
2018-10-11 READ MORE
2018-10-11 READ MORE
2018-10-11 READ MORE

Functionally specific optogenetic modulation in primate visual cortex

Mykyta M. Chernov, Robert M. Friedman, Gang Chen, Gene R. Stoner, and Anna Wang Roe/ PNAS October 9, 2018 115 (41) 10505-10510; published ahead of print September 26, 2018 https://doi.org/10.1073/pnas.1802018115 

 

Significance

Primate visual cortex is organized into columns that process different features of a visual scene, such as color, orientation preference, and ocular dominance. Until now, their small size has made it difficult to modulate them directly. Here, we report for the first time that focal targeting of light-sensitive ion channels (channelrhodopsins) in macaques using lentiviral vectors allows one to stimulate functional domains. We show that such targeted stimulation leads to selective activation of anatomically connected neighboring domains with similar function. Such a fine-scale optical stimulation approach is capable of mapping functionally specific domain-based neuronal networks. Its potential for linking such networks to optogenetic modulation of perception and behavior opens doors for developing targeted, domain-based neuroprosthetics.

Abstract

In primates, visual perception is mediated by brain circuits composed of submillimeter nodes linked together in specific networks that process different types of information, such as eye specificity and contour orientation. We hypothesized that optogenetic stimulation targeted to cortical nodes could selectively activate such cortical networks. We used viral transfection methods to confer light sensitivity to neurons in monkey primary visual cortex. Using intrinsic signal optical imaging and single-unit electrophysiology to assess effects of targeted optogenetic stimulation, we found that (i) optogenetic stimulation of single ocular dominance columns (eye-specific nodes) revealed preferential activation of nearby same-eye columns but not opposite-eye columns, and (ii) optogenetic stimulation of single orientation domains increased visual response of matching orientation domains and relatively suppressed nonmatching orientation selectivity. These findings demonstrate that optical stimulation of single nodes leads to modulation of functionally specific cortical networks related to underlying neural architecture.

Link: http://www.pnas.org/content/115/41/10505

2018-10-18 READ MORE

Brain active transmembrane water cycling measured by MR is associated with neuronal activity(2018). DOI: 10.1002/mrm.27473CV.pdf


Ruiliang Bai,Charles S. Springer Jr.,Dietmar Plenz, Peter J. Basser

 

Significance

We found that neurons absorb and release water when they relay messages throughout the brain. Tracking this water movement with imaging technology may one day provide valuable information on normal brain activity, as well as how injury or disease affect brain function.

Current functional magnetic resonance imaging (fMRI) technologies measure neuronal activity indirectly by tracking changes in blood flow and blood oxygen levels. Neurons communicate with each other by a process known as firing. In this process, they emit a slight electrical charge as an enzyme moves positively charged molecules — potassium and sodium ions — through the cell membrane. In the current study, when we stimulated cell cultures of rat neurons to fire, we found that the exchanges of potassium and sodium ions was accompanied by an increase in the number of water molecules moving into and out of the cell.

We noted that our method works only in cultures of neurons and additional studies are necessary to advance the technology so that it can be used to monitor neuronal firing in living organisms.

Abstract

Purpose: fMRI is widely used to study brain activity. Unfortunately, conventional fMRI methods assess neuronal activity only indirectly, through hemodynamic coupling. Here, we show that active, steadystate transmembrane water cycling (AWC) could serve as a basis for a potential fMRI mechanism for direct neuronal activity detection.

Methods: AWC and neuronal actitivity in rat organotypic cortical cultures were simultaneously measured with a hybrid MRfluorescence system. Perfusion with a paramagnetic MRI contrast agent, Gadoteridol, allows NMR determination of the kinetics of transcytolemmal water exchange. Changes in intracellular calcium concentration, [Cai2+] were used as a proxy of neuronal activity and were monitored by fluorescence imaging.

Results: When we alter neuronal activity by titrating with extracellular [K+] near the normal value, we see an AWC response resembling Na+K+ATPase (NKA) MichaelisMenten behavior. When we treat with the voltagegated sodium channel inhibitor, or with an excitatory postsynaptic inhibitor cocktail, we see AWC decrease by up to 71%. AWC was found also to be positively correlated with the basal level of spontaneous activity, which varies in different cultures.

Conclusions: These results suggest that AWC is associated with neuronal activity and NKA activity is a major contributor in coupling AWC to neuronal activity. Although AWC comprises steadystate, homeostatic transmembrane water exchange, our analysis also yields a simultaneous measure of the average cell volume, which reports any slower net transmembrane water transport.

Keywords

active, fMRI, functional MRI, membrane, transcytolemmal, Na+/K+ ATPase, neuronal activity, pump, water exchange

Online paper: https://doi.org/10.1002/mrm.27473

2018-10-18 READ MORE

Significance

Detection and analyzing visual motion is an important task for the visual system. In the past half a century, research on motion information processing has been focused primarily on the dorsal visual areas (e.g. area MT/V5). Other visual areas (e.g. V2, V4) are virtually unexplored in this aspect, despite the fact that the motion-sensitive neurons in these areas are significantly present and form functional domains. In this study, we combined optical imaging with single-cell recordings to specifically record from direction-selective neurons in the second largest visual area, V2, in macaque monkeys, in order to have a full picture of how motion information is analyzed in the brain.

We found that motion-sensitive neurons in area V2 have characteristic features that are different from those in the well-studied motion areas like area MT. Particularly, these neurons have small receptive field and strong surround suppression, which make them sensitive to “motion contrast”, a key information delineating object boundaries. These features suggest that area V2 detects visual objects based on motion information.

Abstract

In the primate visual system, direction-selective (DS)neurons are critical for visual motion perception. While DS neurons in the dorsal visual pathway have been well characterized, the response properties of DS neurons in other major visual areas are largely unexplored. Recent optical imaging studies in monkey visual cortex area 2 (V2) revealed clusters of DS neurons. This imaging method facilitates targeted recordings from these neurons. Using optical imaging and single-cell recording, we characterized detailed response properties of DS neurons in macaque V2. Compared with DS neurons in the dorsal areas (e.g., middle temporal area [MT]), V2 DS neurons have a smaller receptive field and a stronger antagonistic surround. They do not code speed or plaid motion but are sensitive to motion contrast. Our results suggest that V2 DS neurons play an important role in figure-ground segregation. The clusters of V2 DS neurons are likely specialized functional systems for detecting motion contrast. 

Keywords

Macaque, V2, direction selectivity, RF surround, motion contrast

Online paper: https://www.cell.com/cell-reports/fulltext/S2211-1247(18)31444-X#secsectitle0265pdf.pdf

2018-10-17 READ MORE

Recruiter: Dr.Anna Wang Roe

Email: annawang@zju.edu.cn

Assistant: Ming Xiong xiongming@zju.edu.cn

Research Interest: Cerebral cortex;Visual and perceptual neural mechanisms;touch; attention and cognition;Neurotechnology.

Key Word: Optical Imaging; UHF MRI;Electrophysiology;Non-Human primate(NHP); Optical Stimulation; Behavior. 


Seeking two postdoctoral fellows for monkey connectome project at Zhejiang University.Existing connectomes have offered great advances in our understanding of brain networks.However,greater spatial resolution is needed to observe column-based functionally specific networks.We have developed a new in vivo functional tract tracing technique,combining laser stimulation and 7T fMRI with custom made multiarray coils, to achieve a columnar connectome.We seek candidates with strong (1)fMRI background, (2)computational and mathematical background,and/or (3)optical and engineering background.Any of the following will be considered a plus:fMRI experience,strong quantitative and analytical skills,familiarity with MRI analysis platform (e.g. matlab, AFNI,…),understanding of primate brain circuitry,experience with brain connectomes.Salary is competitive and commensurate with experience.

 

Zhejiang University’s Interdisciplinary Institute of Neuroscience & Technology (ziint.zju.edu.cn/en/index.asp) is home to 15 labs,an MRI center for human and nonhuman primate research,coil making facility,nonhuman primate facility,2 photon and high throughput microscopy,computer cluster,and viral vector core.We foster an environment of exciting collaborative and interdisciplinary interaction.English is the common language;lectures and seminars are given in English.

 

Zhejiang University is located in Hangzhou,China,an hour by bullet train from Shanghai.Home to beautiful West Lake, Hangzhou is both a modern and a historical city,with an emphasis on culture and environment.Direct flights to Hangzhou are available from LAX,Amsterdam,and multiple cities in Asia.

 

Interested candidates should send a CV,names of 3 references,and a statement of research interests to Dr. Anna Wang Roe at annawang@zju.edu.cn.

 

2018-09-19 READ MORE

Recruiter: A/Prof.Ruiliang Bai

Email: ruiliangbai@zju.edu.cn

Research Interests: Novel functional MRI contrasts and methods; Microstructural MRI; Metabolic imaging; CNS disease diagnosis; Stoke diagnosis

Keywords: Brain imaging; High-field MRI; MRI biophysics


A postdoctoral position to conduct ultra-high-field MRI methods development and application studies is available in ZIINT, under the supervision of both Prof.Anna Roe and A/Prof.Ruiling Bai. ZIINT features an MRI center for both human and animal work (Zhejiang University-Siemens Brain Imaging Research Center) which houses a 3T Prisma and 7T Magnetom,MR-compatible sensory stimulus presentation systems, human MR-compatible EEG system,coil making facility, and animal support equipment. 


This project will be focused on developments of MRI sequences and methods on the 7T MRI.The potential directions includes but is not limited to (1) magnetic resonance spectroscopy (MRS) and related imaging techniques;(2) advanced diffusion MRI for microstructure imaging;(3) temperature mapping;(4) high-resolution CBF and CBV imaging.Another direction would be the applications of these newly developed sequences,for example, in the diagnosis of brain disorders by collaborating with hospitals nearby. The candidate will also have the chance to combine other methodologies developed in PI's lab, including optical imaging,neurophysiology, focal brain stimulation methods (electrical, pulsed near infrared stimulation,and optogenetics stimulation).


Candidates should have a strong research background in MRI technique,especially on Siemens platform. Familiarity with Matlab and MRI physics is a plus. Candidate should have ability to work both independently and as part of a team with other neuroscientists, MR physcists, and animal care personnel.


Please send CV,research statement and names of three references to:

Email: ruiliangbai@zju.edu.cn; Salary and rank will be commensurate with experience.

Ruiliang Bai, Associated Professor

Zhejiang University Director of Zhejiang University Interdisciplinary Institute of Neuroscience and Technologe(ZIINT)


2018-09-19 READ MORE

脑科技领域是国家科技发展战略中的重点方向,为了进一步推动脑科学研究与脑机融合技术的科技创新,培养理、工、医等多学科交叉的跨领域人才,浙江大学求是高等研究─系统神经与认知科学研究所【赖欣怡教授课题组】,特面向海内外公开招聘博士后2-3名,竭诚欢迎海内外精英加盟。

浙江大学系统神经与认知科学研究所成立于2013年,主要目标为解决认知与行为神经科学领域的重大问题,探索脑高级功能的神经网络机制,在脑功能和脑疾病等相关研究中取得重大突破;为相关医学、神经科学、工程学以及其他领域交叉学科的沟通搭建了桥梁;同时致力于跨学科研究,将与各大医院紧密合作,使科研成果产业化,真正的推动神经医学的发展。

赖欣怡课题组致力于发展先进的神经工程技术,通过生医微机电技术、超高场磁共振成像技术、神经调控技术、计算神经科学的多学科交叉整合创新,开发脑科学研究及脑疾病诊治需要的关键技术,主要研究:(1)神经调控技术:发展磁兼容聚焦超声及脑深部电刺激技术应用于脑功能与神经精神疾病的研究;(2)脑机接口:研究(非人)灵长类触动觉神经编码机制;(3)生医微机电芯片传感器:采用生医微机电技术开发具复合功能的神经探针与生医微芯片系统。近三年已获3项国家自然科学基金(主持2项、子课题负责人1项)、1项科技部国家重点研发计划(骨干)、2项中央高校科研经费(主持1项、共同主持1项),及1项省级大科学装置研制项目(子课题负责人1项)等资助。

 

【应聘人员基本条件】

1、已取得工程学、生物学、医学或药学等相关专业博士学位。

2、良好的独立科研能力及科学素养、富有责任感和团队协作精神。

3、良好的英文阅读、写作和口头交流能力。

4、年龄35周岁以下,身体健康。

5、以下背景经验者优先考虑:

(1)动物脑手术实验经验。

(2)结构与功能核磁共振影像分析。

(3)神经电生理数据分析及神经信息编码与解码模型。

(4)良好的编程能力,熟悉Matlab、C或R语言。

(5)生医微机电制程及芯片设计经验。

【工作待遇】

    工资及福利待遇按国家博士后相关规定执行,年薪一般15 - 20万元人民币;优秀博士可申请浙江大学国际交流计划引进项目,获批年薪可达30万元人民币;提供教师公寓(优惠价租赁)

 

【需提供的材料】

申请者通过电子邮件,邮件主题请注明:“博士后应聘_姓名”,提供如下材料:

1、个人简历(包括一般情况、受教育经历、工作经历、专业技能及特长、各类研究项目、各类发表论文、各类奖励等);

2、2~5篇代表性论文的PDF全文版;

3、研究兴趣及受聘后的工作设想和目标。

 

【联系方式】

赖欣怡教授

联系邮箱:laihy@zju.edu.cn

2018-05-03 READ MORE

SHARED FACILITY

  • Highfield MRI

  • Nonhuman Primate Facility

  • Two Photon Microscopy

  • High Throughput Microscopy

  • RF Coil

  • 3Dprinting and Machinng

  • Computer Cluster

  • Viral Vector Core

  • Highfield MRI

  • Nonhuman Primate Facility

  • Two Photon Microscopy

  • High Throughput Microscopy

  • RF Coil

  • 3Dprinting and Machinng

  • Computer Cluster

  • Viral Vector Core

THE TEAM

ABOUT US

Zhejiang University Interdisciplinary Institute of Neuroscience and Technology (ZIINT) was founded in 2013 by Prof. Anna Wang Roe on Huajiachi Campus. Prof. Anna Wang Roe is an internationally well-recognized scentisit in the field of neuroscience and its related interdisciplines. The ultimate goal of ZIINT is to do fundamental researches in the field of cognitive and behavioral neuroscience, to explore the neural network mechanism of brain advanced function, and to achieve major breakthroughs in brain function and brain diseases. Another goal of ZIINT is to establish links for related disciplines in fields of medicine, neuroscience, engineering and other fields, and work closely with major industries and hospitals to develop new technologies for neuroscience studies and promote our fundamental researches for clinical translation.


Currently, ZIINT has the only actively shielded 7T Ultra-High field magnetic resonance system - the "MAGNATOM 7T" in China, and a live-two-photon imaging system, and also has the top neuroscience and brain cognitive research equipment with automatic, high-throughput, high-speed fluorescence scanning systems recognized by the scientific community, moreover the institute has established 20 basic research laboratories, and is equipped with multiple public experimental platforms to support each laboratories working.


Since the establishment of ZIINT, 16 outstanding PIs have been recruited, they have good academic literacy and profound research capacity, involving a wide range of research fields. A total of 25 funding projects have been awarded by the National Science Fund for Distinguished Young Scholars, the Fund Development Committee Major Research Project Nurturing Project, the National Natural Science Foundation of China, the 973 Scientific and Technological Problem - Oriented Project of the Ministry of Science and Technology, and the National 863 Program. Since our enrollment in 2014, we have already recruited 34 doctoral students and 13 master students. At the same time, high-quality cross-disciplinary international conferences such as "Frontiers in Interdisciplinary Neuroscience and Technology" and "Asia-Pacific Symposium on Advances in UHF MRI" high-field magnetic resonance and other meetings are held each year. The sharing of research experience and technology provides an international front-line communication platform to further promote the development of the field and the exploration of new fields in cross-disciplines. At the same time, we conduct collaboration program with a number of hospitals in Hangzhou to directly promote scientific research achievements conversion.


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